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Literature DB >> 3886557

Mutagenicity of 4,4'-methylene-bis-(2-chloroaniline) "MOCA" and its N-acetyl derivatives in S. typhimurium.

Abstract

4,4'-methylene-bis-(2-chloroaniline) ("MOCA") and two identified urinary N-acetyl and N,N'-diacetyl derivatives were tested in a Salmonella/mammalian microsome assay. No mutagenic activity was observed without rat liver S9 mix activation. In the presence of rat liver S9 mix, the chemicals were mutagens, but the mutagenicity of N-acetyl derivatives to strain TA100 was reduced when compared to that of "MOCA", and a greater amount of S9 was required to exhibit the mutagenicity of the N,N'-diacetyl-"MOCA". These data suggest that N-acetylation does not account for the mutagenic effectiveness of "MOCA".

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Year: 1985 PMID： 3886557 DOI： 10.1007/bf00378379

Source DB: PubMed Journal: Int Arch Occup Environ Health ISSN： 0340-0131 Impact factor: 3.015

13 in total

1. The carcinogenic effect of 4,4'-methylene-bis-(2-chloroaniline) in mice and rats.

Authors: A B Russfield; F Homburger; E Boger; C G Van Dongen; E K Weisburger; J H Weisburger
Journal: Toxicol Appl Pharmacol Date: 1975-01 Impact factor: 4.219

2. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Authors: J McCann; E Choi; E Yamasaki; B N Ames
Journal: Proc Natl Acad Sci U S A Date: 1975-12 Impact factor: 11.205

3. Assessment of occupational exposure to 4,4'-methylene-bis-(2-chloroaniline) "MOCA" by a new sensitive method for biological monitoring.

Authors: P Ducos; C Maire; R Gaudin
Journal: Int Arch Occup Environ Health Date: 1985 Impact factor: 3.015

2. Assessment of occupational exposure to 4,4'-diaminodiphenylmethane (methylene dianiline) by gas chromatography-mass spectrometry analysis of urine.

Authors: J Cocker; W Gristwood; H K Wilson
Journal: Br J Ind Med Date: 1986-09

2 in total

Mutagenicity of 4,4'-methylene-bis-(2-chloroaniline) "MOCA" and its N-acetyl derivatives in S. typhimurium.

1. The carcinogenic effect of 4,4'-methylene-bis-(2-chloroaniline) in mice and rats.

2. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

3. Assessment of occupational exposure to 4,4'-methylene-bis-(2-chloroaniline) "MOCA" by a new sensitive method for biological monitoring.

4. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.

5. An electron spin resonance study of the activation of benzidine by peroxidases.

6. The genotoxicity of 4,4'-methylenebis-2-chloroaniline in rat, mouse, and hamster hepatocytes.

7. Urinary bladder tumors in dogs from 4,4'-methylene-bis (2-chloroaniline) (MOCA).

8. The association of the slow acetylator phenotype with bladder cancer.

9. Concepts in causality: chemically induced human urinary bladder cancer.

10. Determination of the tumorigenic potential of methylene-bis-orthochloroaniline.

1. Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation.

2. Assessment of occupational exposure to 4,4'-diaminodiphenylmethane (methylene dianiline) by gas chromatography-mass spectrometry analysis of urine.