Literature DB >> 3886543

Immunochemistry of the Streptococcus mutans BHT cell membrane: detection of determinants cross-reactive with human heart tissue.

G Y Ayakawa, J L Siegel, P J Crowley, A S Bleiweis.   

Abstract

Cell membranes of Streptococcus mutans BHT serotype b were prepared after glass bead disruption or mutanolysin digestion of whole cells. Immunoblot analyses of BHT membrane extracts revealed major polypeptides of 42,000, 46,000, 62,000, and 82,000 daltons, as well as several minor bands, to be reactive with rabbit anti-human heart immunoglobulins. Heart cross-reactive antigens have been reported in the cell walls and culture fluids of several S. mutans serotypes. This represents the first report of cell membrane-localized heart cross-reactive antigens in this oral pathogen. Positive enzyme-linked immunosorbent assay and immunoblot reactions were also obtained with heart tissue antigen and anti-BHT sera, indicating mutual cross-reactivity. The major cross-reactive component detected by immunoblotting of human heart extracts was a 69,000-dalton polypeptide.

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Year:  1985        PMID： 3886543      PMCID： PMC261301          DOI： 10.1128/iai.48.2.280-286.1985

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  28 in total

1.  Characterisation of antigens extracted from cells and culture fluids of Streptococcus mutans serotype c.

Authors:  M W Russell; T Lehner
Journal:  Arch Oral Biol       Date:  1978       Impact factor: 2.633

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Immunisation with a purified protein from Streptococcus mutans against dental caries in rhesus monkeys.

Authors:  T Lehner; M W Russell; J Caldwell
Journal:  Lancet       Date:  1980-05-10       Impact factor: 79.321

5.  Growth of several cariogenic strains of oral streptococci in a chemically defined medium.

Authors:  B Terleckyj; N P Willett; G D Shockman
Journal:  Infect Immun       Date:  1975-04       Impact factor: 3.441

6.  Immunization against dental caries.

Authors:  W H Bowen; B Cohen; M F Cole; G Colman
Journal:  Br Dent J       Date:  1975-07-15       Impact factor: 1.626

7.  Wall-associated protein antigens of Streptococcus mutans.

Authors:  R R Russell
Journal:  J Gen Microbiol       Date:  1979-09

8.  Antigens of Streptococcus mutans. I. Characterization of a serotype-specific determinant from Streptococcus mutans.

Authors:  I Van de Rijn; A S Bleiweis
Journal:  Infect Immun       Date:  1973-05       Impact factor: 3.441

9.  Evidence for an immunological relationship between Streptococcus mutans and human cardiac tissue.

Authors:  M Hughes; S M Machardy; A J Sheppard; N C Woods
Journal:  Infect Immun       Date:  1980-02       Impact factor: 3.441

10.  Group A streptococcal antigens cross-reactive with myocardium. Purification of heart-reactive antibody and isolation and characterization of the streptococcal antigen.

Authors:  I van de Rijn; J B Zabriskie; M McCarty
Journal:  J Exp Med       Date:  1977-08-01       Impact factor: 14.307
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  7 in total

Review 1.  Recent advances in the development of a Streptococcus mutans vaccine.

Authors:  J P Klein; M Scholler
Journal:  Eur J Epidemiol       Date:  1988-12       Impact factor: 8.082

2.  Immunological cross-reactivity between Streptococcus mutans and human heart tissue examined by cross-immunization experiments.

Authors:  H Y Wu; M W Russell
Journal:  Infect Immun       Date:  1990-11       Impact factor: 3.441

3.  Isolation and characterization of monoclonal antibodies specific for antigen P1, a major surface protein of mutans streptococci.

Authors:  G Y Ayakawa; L W Boushell; P J Crowley; G W Erdos; W P McArthur; A S Bleiweis
Journal:  Infect Immun       Date:  1987-11       Impact factor: 3.441

4.  Structural studies of the rhamnose-glucose polysaccharide antigen from Streptococcus sobrinus B13 and 6715-T2.

Authors:  R Linzer; M S Reddy; M J Levine
Journal:  Infect Immun       Date:  1985-11       Impact factor: 3.441

5.  Activation of human monocytes by Streptococcus mutans serotype f polysaccharide: immunoglobulin G Fc receptor expression and tumor necrosis factor and interleukin-1 production.

Authors:  S Benabdelmoumene; S Dumont; C Petit; P Poindron; D Wachsmann; J P Klein
Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

Review 6.  Insight into status of dental caries vaccination: A review.

Authors:  Gayathri Cherukuri; Chandrasekhar Veeramachaneni; G V Rao; Venkat Baghirath Pacha; Sudheer B Balla
Journal:  J Conserv Dent       Date:  2021-02-11

7.  Antibodies generated against dextransucrase exhibit potential anticariostatic properties in Streptococcus mutans.

Authors:  Shabeer Ahmad Rather; Sukesh Chander Sharma; Akhtar Mahmood
Journal:  Appl Microbiol Biotechnol       Date:  2020-01-03       Impact factor: 4.813
  7 in total

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