Literature DB >> 388619

Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes.

A A Like, A A Rossini, D L Guberski, M C Appel, R M Williams.   

Abstract

Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.

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Year:  1979        PMID： 388619     DOI： 10.1126/science.388619

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  55 in total

Review 1.  The CXCR1/2 Pathway: Involvement in Diabetes Pathophysiology and Potential Target for T1D Interventions.

Authors:  Antonio Citro; Elisa Cantarelli; Lorenzo Piemonti
Journal:  Curr Diab Rep       Date:  2015-10       Impact factor: 4.810

2.  Diabetes mellitus in the BB/W rat. Insulitis in pancreatic islet grafts after transplantation in diabetic recipients.

Authors:  E J Weringer; A A Like
Journal:  Am J Pathol       Date:  1986-10       Impact factor: 4.307

3.  Resistance to tolerance induction in the diabetes-prone biobreeding rat as one manifestation of abnormal responses to superantigens.

Authors:  K S Sellins; D P Gold; D Bellgrau
Journal:  Diabetologia       Date:  1996-01       Impact factor: 10.122

4.  Antibodies spontaneously bound to islet cells in diabetic C57BL/KsJ db/db mice.

Authors:  P Sai; M Kremer; C Maurel
Journal:  Diabetologia       Date:  1984-07       Impact factor: 10.122

5.  Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A.

Authors:  A A Like; V Dirodi; S Thomas; D L Guberski; A A Rossini
Journal:  Am J Pathol       Date:  1984-10       Impact factor: 4.307

6.  Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat.

Authors:  T Dyrberg; P Poussier; F Nakhooda; E B Marliss; A Lernmark
Journal:  Diabetologia       Date:  1984-02       Impact factor: 10.122

Review 7.  Clinical immunologic interventions for the treatment of type 1 diabetes.

Authors:  Lucienne Chatenoud; Katharina Warncke; Anette-G Ziegler
Journal:  Cold Spring Harb Perspect Med       Date:  2012-08-01       Impact factor: 6.915

8.  Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.

Authors:  A A Rossini; D Faustman; B A Woda; A A Like; I Szymanski; J P Mordes
Journal:  J Clin Invest       Date:  1984-07       Impact factor: 14.808

9.  WIN 54954 treatment of mice infected with a diabetogenic strain of group B coxsackievirus.

Authors:  D M See; J G Tilles
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

Review 10.  Type 1 diabetes mellitus: an imbalance between effector and regulatory T cells?

Authors:  E J Rashba; E P Reich; C A Janeway; R S Sherwin
Journal:  Acta Diabetol       Date:  1993       Impact factor: 4.280
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