Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.

Literature DB >> 3885396

Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.

W I Frels, J A Bluestone, R J Hodes, M R Capecchi, D S Singer.

Abstract

A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were rejected by normal C57BL/10 mice, suggesting that the foreign SLA antigen expressed in the transgenic mice is recognized as a functional transplantation antigen.

Entities: Gene Species

Mesh：

Substances：
H-2 Antigens
DNA

Year: 1985 PMID： 3885396 DOI： 10.1126/science.3885396

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

23 in total

Review 1. Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.

Authors: T Kevin Howcroft; Dinah S Singer
Journal: Immunol Res Date: 2003 Impact factor: 2.829

2. In vivo function of regulatory DNA sequence elements of a major histocompatibility complex class I gene.

Authors: J E Maguire; W I Frels; J C Richardson; J D Weissman; D S Singer
Journal: Mol Cell Biol Date: 1992-07 Impact factor: 4.272

3. ATG deserts define a novel core promoter subclass.

Authors: Maxwell P Lee; Kevin Howcroft; Aparna Kotekar; Howard H Yang; Kenneth H Buetow; Dinah S Singer
Journal: Genome Res Date: 2005-08-18 Impact factor: 9.043

4. Major histocompatibility complex class I core promoter elements are not essential for transcription in vivo.

Authors: Zohar S Barbash; Jocelyn D Weissman; John A Campbell; Jie Mu; Dinah S Singer
Journal: Mol Cell Biol Date: 2013-09-09 Impact factor: 4.272

5. Histone modifications, but not nucleosomal positioning, correlate with major histocompatibility complex class I promoter activity in different tissues in vivo.

Authors: Aparna S Kotekar; Jocelyn D Weissman; Anne Gegonne; Helit Cohen; Dinah S Singer
Journal: Mol Cell Biol Date: 2008-09-22 Impact factor: 4.272

Review 6. Germ-line transformation of mice.

Authors: R D Palmiter; R L Brinster
Journal: Annu Rev Genet Date: 1986 Impact factor: 16.830

Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.

Review 1. Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.

2. In vivo function of regulatory DNA sequence elements of a major histocompatibility complex class I gene.

3. ATG deserts define a novel core promoter subclass.

4. Major histocompatibility complex class I core promoter elements are not essential for transcription in vivo.

5. Histone modifications, but not nucleosomal positioning, correlate with major histocompatibility complex class I promoter activity in different tissues in vivo.

Review 6. Germ-line transformation of mice.

7. Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function.

8. Regulated expression of a murine class I gene in transgenic mice.

9. Distinct transcriptional pathways regulate basal and activated major histocompatibility complex class I expression.

10. In vivo expression of MHC class I genes depends on the presence of a downstream barrier element.