Literature DB >> 388431

Interference of nonsense mutations with eukaryotic messenger RNA stability.

R Losson, F Lacroute.   

Abstract

The fine structure map of the yeast URA 3 gene was established by meiotic recombination, and amber nonsense mutations were located at different points on the map. The effect of the length of the labeling time on the specific radioactivity of ura 3 messenger RNA and on its repartition between poly(A)-RNA and RNA not containing poly(A) has been followed in nonsense mutants. Nonsense mutations reduce the messenger level without lowering its instantaneous rate of synthesis. The strength of the reduction depends on the position of the nonsense codon within the locus and concerns essentially the accumulation of polyadenylylated ura 3 mRNA.

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Year:  1979        PMID： 388431      PMCID： PMC413094          DOI： 10.1073/pnas.76.10.5134

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

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Authors:  M CANNON; R KRUG; W GILBERT
Journal:  J Mol Biol       Date:  1963-10       Impact factor: 5.469

2.  Execution times of macromolecular synthetic processes involved in the induction of allophanate hydrolase at 15 degrees C.

Authors:  J Bossinger; T G Cooper
Journal:  J Bacteriol       Date:  1976-10       Impact factor: 3.490

3.  Orotidylate decarboxylase (yeast).

Authors:  A Yoshimoto; K Umezu; K Kobayashi; K Tomita
Journal:  Methods Enzymol       Date:  1978       Impact factor: 1.600

4.  Translation and mRNA decay.

Authors:  E Schneider; M Blundell; D Kennell
Journal:  Mol Gen Genet       Date:  1978-04-06

5.  High stability of messenger RNA in growing cultured cells.

Authors:  J R Greenberg
Journal:  Nature       Date:  1972-11-10       Impact factor: 49.962

6.  Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.

Authors:  D B Clewell
Journal:  J Bacteriol       Date:  1972-05       Impact factor: 3.490

Review 7.  Processing of RNA.

Authors:  R P Perry
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

8.  Turnover of polyadenylated messenger RNA in fission yeast. Evidence for the control of protein synthesis at the translational level.

Authors:  R S Fraser
Journal:  Eur J Biochem       Date:  1975-12-15

9.  Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coli.

Authors:  M L Bach; F Lacroute; D Botstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

10.  Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.

Authors:  F Bolivar; R L Rodriguez; P J Greene; M C Betlach; H L Heyneker; H W Boyer; J H Crosa; S Falkow
Journal:  Gene       Date:  1977       Impact factor: 3.688
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  204 in total

1.  Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.

Authors:  D Muhlrad; R Parker
Journal:  Mol Biol Cell       Date:  1999-11       Impact factor: 4.138

Review 2.  mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

Authors:  P Hilleren; R Parker
Journal:  RNA       Date:  1999-06       Impact factor: 4.942

3.  Boundary-independent polar nonsense-mediated decay.

Authors:  Jun Wang; Jayanthi P Gudikote; O Renee Olivas; Miles F Wilkinson
Journal:  EMBO Rep       Date:  2002-02-15       Impact factor: 8.807

4.  The fitness of defective interfering murine coronavirus DI-a and its derivatives is decreased by nonsense and frameshift mutations.

Authors:  R J de Groot; R G van der Most; W J Spaan
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

5.  Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.

Authors:  V Kodoyianni; E M Maine; J Kimble
Journal:  Mol Biol Cell       Date:  1992-11       Impact factor: 4.138

6.  Global regulation of mitochondrial biogenesis in Saccharomyces cerevisiae: ABF1 and CPF1 play opposite roles in regulating expression of the QCR8 gene, which encodes subunit VIII of the mitochondrial ubiquinol-cytochrome c oxidoreductase.

Authors:  J H de Winde; L A Grivell
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

Review 7.  Mechanisms of deadenylation-dependent decay.

Authors:  Chyi-Ying A Chen; Ann-Bin Shyu
Journal:  Wiley Interdiscip Rev RNA       Date:  2010-09-15       Impact factor: 9.957

Review 8.  Genome-wide technology for determining RNA stability in mammalian cells: historical perspective and recent advantages based on modified nucleotide labeling.

Authors:  Hidenori Tani; Nobuyoshi Akimitsu
Journal:  RNA Biol       Date:  2012-10-01       Impact factor: 4.652

9.  Photoaffinity labeling and characterization of the cloned purine-cytosine transport system in Saccharomyces cerevisiae.

Authors:  R Schmidt; M F Manolson; M R Chevallier
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

10.  Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

Authors:  P Belgrader; J Cheng; X Zhou; L S Stephenson; L E Maquat
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272
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