Literature DB >> 3883639

In vitro antimicrobial activity of hydroxy and N4-acetyl sulphonamide metabolites.

J F Nouws, T B Vree, Y A Hekster.   

Abstract

Hydroxylated metabolites of sulphadimidine, sulphamerazine, sulphatroxazole, sulphamethoxazole, and sulphadiazine exhibited antimicrobial activity against Escherichia coli 28 PR 271 test strain ranging from 2.5 to 39.5 per cent of that of the parent drug. Trimethoprim addition potentiated the antimicrobial activity of these metabolites. N4-acetyl sulphonamide metabolites possessed no antimicrobial activity, nor did trimethoprim potentiated them.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3883639     DOI： 10.1080/01652176.1985.9693956

Source DB:  PubMed          Journal:  Vet Q        ISSN： 0165-2176            Impact factor:   3.320


  6 in total

1.  Structural characterization of sulfadiazine metabolites using H/D exchange combined with various MS/MS experiments.

Authors:  Thomas Pfeifer; Jochen Tuerk; Regine Fuchs
Journal:  J Am Soc Mass Spectrom       Date:  2005-10       Impact factor: 3.109

2.  Occurrence and sources of antibiotics and their metabolites in river water, WWTPs, and swine wastewater in Jiulongjiang River basin, south China.

Authors:  Hongyou Jiang; Dandan Zhang; Shichang Xiao; Chunnv Geng; Xian Zhang
Journal:  Environ Sci Pollut Res Int       Date:  2013-06-28       Impact factor: 4.223

3.  Pharmacokinetics of cefradine, sulfamethoxazole and trimethoprim and their metabolites in a patient with peritonitis undergoing continuous ambulatory peritoneal dialysis.

Authors:  M Martea; Y A Hekster; T B Vree; A J Voets; J H Berden
Journal:  Pharm Weekbl Sci       Date:  1987-04-24

4.  In vitro effects of sulfadiazine and its metabolites alone and in combination with pyrimethamine on Toxoplasma gondii.

Authors:  E Schoondermark-van de Ven; T Vree; W Melchers; W Camps; J Galama
Journal:  Antimicrob Agents Chemother       Date:  1995-03       Impact factor: 5.191

5.  Occurrence and removal of sulfonamides and their acetyl metabolites in a biological aerated filter (BAF) of wastewater treatment plant in Xiamen, South China.

Authors:  Dapeng Wang; Xian Zhang; Changzhou Yan
Journal:  Environ Sci Pollut Res Int       Date:  2019-09-14       Impact factor: 4.223

6.  The effect of miscellaneous oral dosage forms on the environmental pollution of sulfonamides in pig holdings.

Authors:  Jessica Stahl; Katrin Zessel; Jochen Schulz; Jan Henrik Finke; Christel Charlotte Müller-Goymann; Manfred Kietzmann
Journal:  BMC Vet Res       Date:  2016-04-01       Impact factor: 2.741
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.