Literature DB >> 3883489

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids.

A H Fairlamb, P Blackburn, P Ulrich, B T Chait, A Cerami.   

Abstract

Glutathione reductase from trypanosomes and leishmanias, unlike glutathione reductase from other organisms, requires an unusual low molecular weight cofactor for activity. The cofactor was purified from the insect trypanosomatid Crithidia fasciculata and identified as a novel glutathione-spermidine conjugate, N1,N8-bis(L-gamma-glutamyl-L-hemicystinyl-glycyl)spermidine, for which the trivial name trypanothione is proposed. This discovery may open a new chemotherapeutic approach to trypanosomiasis and leishmaniasis.

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Year:  1985        PMID： 3883489     DOI： 10.1126/science.3883489

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  128 in total

1.  Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.

Authors:  T J Benson; J H McKie; J Garforth; A Borges; A H Fairlamb; K T Douglas
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

2.  Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani.

Authors:  Bidyut Purkait; Ashish Kumar; Nilay Nandi; Abul Hasan Sardar; Sushmita Das; Sudeep Kumar; Krishna Pandey; Vidyananda Ravidas; Manish Kumar; Tripti De; Dharmendra Singh; Pradeep Das
Journal:  Antimicrob Agents Chemother       Date:  2011-11-28       Impact factor: 5.191

3.  Glutathione.

Authors:  Graham Noctor; Guillaume Queval; Amna Mhamdi; Sejir Chaouch; Christine H Foyer
Journal:  Arabidopsis Book       Date:  2011-02-18

4.  Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.

Authors:  Matthew P Fitzgerald; Joshua M Madsen; Mitchell C Coleman; Melissa L T Teoh; Scott G Westphal; Douglas R Spitz; Rafael Radi; Frederick E Domann
Journal:  Radiat Res       Date:  2010-09       Impact factor: 2.841

5.  Trypanothione is the primary target for arsenical drugs against African trypanosomes.

Authors:  A H Fairlamb; G B Henderson; A Cerami
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

6.  Molecular Docking and in Vitro Antileishmanial Evaluation of Chromene-2-thione Analogues.

Authors:  Rajiv Kumar Verma; Vijay Kumar Prajapati; Girijesh Kumar Verma; Deblina Chakraborty; Shyam Sundar; Madhukar Rai; Vikash Kumar Dubey; Maya Shankar Singh
Journal:  ACS Med Chem Lett       Date:  2012-01-18       Impact factor: 4.345

7.  Ammonium trichloro [1,2-ethanediolato-O,O']-tellurate cures experimental visceral leishmaniasis by redox modulation of Leishmania donovani trypanothione reductase and inhibiting host integrin linked PI3K/Akt pathway.

Authors:  Preeti Vishwakarma; Naveen Parmar; Pragya Chandrakar; Tanuj Sharma; Manoj Kathuria; Pramod K Agnihotri; Mohammad Imran Siddiqi; Kalyan Mitra; Susanta Kar
Journal:  Cell Mol Life Sci       Date:  2017-09-12       Impact factor: 9.261

8.  A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major.

Authors:  Tim J Vickers; Neil Greig; Alan H Fairlamb
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-25       Impact factor: 11.205

9.  Redox potential regulates binding of universal minicircle sequence binding protein at the kinetoplast DNA replication origin.

Authors:  Itay Onn; Neta Milman-Shtepel; Joseph Shlomai
Journal:  Eukaryot Cell       Date:  2004-04

10.  Trypanothione S-transferase activity in a trypanosomatid ribosomal elongation factor 1B.

Authors:  Tim J Vickers; Alan H Fairlamb
Journal:  J Biol Chem       Date:  2004-04-08       Impact factor: 5.157
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