Literature DB >> 3881642

Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity.

T L Pazdernik, K K Rozman.   

Abstract

Radiothyroidectomy protected against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity in rats as assessed by the spleen anti-SRBC plaque-forming cell assay. Thyroxine (T4) replacement therapy partially reversed the effects of thyroidectomy on T4 and triiodothyronine (T3) serum levels, body weight and immune function as well as restored TCDD-induced immunotoxicity. Thus, hypothyroidism induced by TCDD exposure can be viewed as a protective response of the organism to reduce the insult caused by TCDD.

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Year:  1985        PMID： 3881642     DOI： 10.1016/0024-3205(85)90175-4

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  5 in total

1.  Toxicity of 3,4,5,3',4',5'-hexachlorobiphenyl to mink.

Authors:  R J Aulerich; S J Bursian; M G Evans; J R Hochstein; K A Koudele; B A Olson; A C Napolitano
Journal:  Arch Environ Contam Toxicol       Date:  1987-01       Impact factor: 2.804

2.  Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in cold-adapted rats.

Authors:  K Rozman; H Greim
Journal:  Arch Toxicol       Date:  1986-12       Impact factor: 5.153

3.  Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria.

Authors:  Y E Sopena de Kracoff; A M Ferramola de Sancovich; H A Sancovich; D L Kleiman de Pisarev
Journal:  J Endocrinol Invest       Date:  1994-05       Impact factor: 4.256

Review 4.  Vulnerability of the developing brain to thyroid abnormalities: environmental insults to the thyroid system.

Authors:  S P Porterfield
Journal:  Environ Health Perspect       Date:  1994-06       Impact factor: 9.031

Review 5.  Multifunctional receptor model for dioxin and related compound toxic action: possible thyroid hormone-responsive effector-linked site.

Authors:  J D McKinney
Journal:  Environ Health Perspect       Date:  1989-07       Impact factor: 9.031
  5 in total

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