| Literature DB >> 3881585 |
N L Colbry, E F Elslager, L M Werbel.
Abstract
The synthesis and antimalarial activity of a series of 2,4,6-triaminopyrido[3,2-d]pyrimidines (4) is described. Several 6-substituted benzylmethylamino analogues were more active against trophozoite induced Plasmodium berghei in mice than the corresponding quinazoline analogues. These agents, however, are cross-resistant to other antifolate compounds and are thus of limited potential as human agents.Entities:
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Year: 1985 PMID： 3881585 DOI： 10.1021/jm00380a018
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446