Literature DB >> 3881280

A novel immunoassay with direct relevance to protection against organophosphate poisoning.

E Heldman, A Balan, O Horowitz, S Ben-Zion, M Torten.   

Abstract

Antiparaoxon immune sera were employed in a new immunoassay based on competition between acetylcholinesterase and antibodies for the binding of paraoxon. Unlike radioimmunoassay, the new assay described herein can be extended to predict the feasibility of antibodies to confer in vivo protection of acetylcholinesterase against organophosphate poisoning. The toxicity of paraoxon was reduced in mice which were preinjected with the immune sera.

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Year:  1985        PMID: 3881280     DOI: 10.1016/0014-5793(85)81079-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  1 in total

1.  Production and characterization of antibodies directed against organophosphorus nerve agent VX.

Authors:  J M Grognet; T Ardouin; M Istin; A Vandais; J P Noel; G Rima; J Satge; C Pradel; H Sentenac-Roumanou; C Lion
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

  1 in total

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