Literature DB >> 3881273

The effect of cyproheptadine on insulin biosynthesis.

R Kikkawa, D Duvillard, W Stauffacher.   

Abstract

The effect of a potent antiserotonin-antihistaminic compound, cyproheptadine (CPH) on insulin biosynthesis was studied in pancreatic islets isolated from CPH-treated rats. Though insulin content of islets was markedly reduced in CPH-treated rats, the incorporation of radiolabeled leucine into proinsulin and insulin fractions was not affected with respect to the rate and amount. It is concluded that CPH may deplete insulin content of the islets through causing the leakage of insulin.

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Year:  1985        PMID： 3881273     DOI： 10.1007/bf02005886

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  The isolation of insulin from a single cat pancreas.

Authors:  P R DAVOREN
Journal:  Biochim Biophys Acta       Date:  1962-09-10

2.  Ultrastructural study of alterations in beta cells of pancreatic islets from cyproheptadine-treated rats.

Authors:  D S Longnecker; J S Wold; L J Fischer
Journal:  Diabetes       Date:  1972-02       Impact factor: 9.461

3.  Species dependent pancreatic islet toxicity produced by cyproheptadine: alterations in beta cell structure and function.

Authors:  J S Wold; D S Longnecker; L J Fischer
Journal:  Toxicol Appl Pharmacol       Date:  1971-06       Impact factor: 4.219

4.  Method for the isolation of intact islets of Langerhans from the rat pancreas.

Authors:  P E Lacy; M Kostianovsky
Journal:  Diabetes       Date:  1967-01       Impact factor: 9.461

5.  Coated charcoal immunoassay of insulin.

Authors:  V Herbert; K S Lau; C W Gottlieb; S J Bleicher
Journal:  J Clin Endocrinol Metab       Date:  1965-10       Impact factor: 5.958

6.  Effects of cyproheptadine on insulin secretion by isolated perifused rat islets.

Authors:  B P Richardson; M L McDaniel; P E Lacy
Journal:  Diabetes       Date:  1975-09       Impact factor: 9.461

7.  Inhibition o'f insulin release by cyproheptadine: effects on 3',5'-cyclic-AMP-content and 45Ca-accumulation of incubated mouse islets.

Authors:  H G Joost; J Beckmann; S Lenzen; A Hasselblatt
Journal:  Acta Endocrinol (Copenh)       Date:  1976-05

8.  Human serum proinsulin.

Authors:  F Melani; A H Rubenstein; D F Steiner
Journal:  J Clin Invest       Date:  1970-03       Impact factor: 14.808

9.  Inhibition of insulin and glucagon release from the perfused rat pancreas by cyproheptadine (Periactinol, Nuran).

Authors:  H G Joost; J Beckmann; S Holze; S Lenzen; W Poser; A Hasselblatt
Journal:  Diabetologia       Date:  1976-07       Impact factor: 10.122

10.  The effects of cyproheptadine on glucose tolerance and pancreatic islets in rats.

Authors:  R Kikkawa; D Duvillard; W Stauffacher
Journal:  Acta Diabetol Lat       Date:  1981 Apr-Jun
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