Literature DB >> 3881088

Correlation of the vasoconstriction assay and clinical activity in psoriasis.

R C Cornell, R B Stoughton.   

Abstract

A large group of glucocorticosteroid formulations were assayed by the vasoconstriction test in normal skin sites and paired comparison studies in patients with psoriasis. Excellent correlation between the vasoconstriction assay and selected paired comparison studies occurred in 20 of 23 instances. In three instances, involving two glucocorticosteroid formulations tested, correlation was absent. The vasoconstrictor assay is an inexpensive and reliable method for screening glucocorticosteroid formulations for clinical activity in psoriasis.

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Year:  1985        PMID： 3881088

Source DB:  PubMed          Journal:  Arch Dermatol        ISSN： 0003-987X


  21 in total

1.  Feasibility of measuring the bioavailability of topical betamethasone dipropionate in commercial formulations using drug content in skin and a skin blanching bioassay.

Authors:  L K Pershing; B S Silver; G G Krueger; V P Shah; J P Skelley
Journal:  Pharm Res       Date:  1992-01       Impact factor: 4.200

2.  Liposome encapsulation improves efficacy of betamethasone dipropionate in atopic eczema but not in psoriasis vulgaris.

Authors:  H C Korting; H Zienicke; M Schäfer-Korting; O Braun-Falco
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

3.  The bioavailability of dermatological and other topically administered drugs.

Authors:  R H Guy; A H Guy; H I Maibach; V P Shah
Journal:  Pharm Res       Date:  1986-10       Impact factor: 4.200

4.  Efficacy, Safety, and Potency of Betamethasone Dipropionate Spray 0.05%: A Treatment for Adults with Mild-to-moderate Plaque Psoriasis.

Authors:  Srinivas Sidgiddi; Refika I Pakunlu; Kent Allenby
Journal:  J Clin Aesthet Dermatol       Date:  2018-04-01

Review 5.  Clinical pharmacology and pharmacokinetic properties of topically applied corticosteroids. A review.

Authors:  K L Goa
Journal:  Drugs       Date:  1988       Impact factor: 9.546

Review 6.  Corticosteroid therapy in acute respiratory distress syndrome.

Authors:  François Lamontagne; Roy Brower; Maureen Meade
Journal:  CMAJ       Date:  2012-11-12       Impact factor: 8.262

7.  Influence of drug solubility in the vehicle on clinical efficacy of ointments.

Authors:  E Malzfeldt; P Lehmann; G Goerz; B C Lippold
Journal:  Arch Dermatol Res       Date:  1989       Impact factor: 3.017

8.  A novel contact hypersensitivity model for rank-ordering formulated corticosteroids.

Authors:  S C Bailey; F Asghar; P A Przekop; E S Kurtz
Journal:  Inflamm Res       Date:  1995-08       Impact factor: 4.575

9.  A comparative clinical evaluation of once daily versus alternate day application of topical clobetasol propionate cream in psoriasis.

Authors:  Afroz Abidi; Farida Ahmad; Satyendra K Singh
Journal:  J Clin Diagn Res       Date:  2012-10-31

10.  Dose-response relationship of topically applied methylprednisolone aceponate (MPA) in healthy volunteers.

Authors:  A Kecskés; P Jahn; H Wendt; L Lange; R K Kuhlmann
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953
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