Literature DB >> 3881076

Cancer in the elderly: basic science and clinical aspects.

D A Lipschitz, S Goldstein, R Reis, M E Weksler, R Bressler, B A Neilan.   

Abstract

The incidence of cancer increases progressively with age. Rearrangements of genomes have been found to accompany cellular aging. These factors, in concert with age-dependent alterations in immune function and host defense, may help to explain the increased risk of malignant disease in aged persons. The clinical presentation and natural history of neoplasia are also affected by aging. This conference reviews recent developments in these areas, examines the effects of drug use in the elderly and implications for management, and discusses current information on how age may influence the response of cancer to therapy.

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Year:  1985        PMID： 3881076     DOI： 10.7326/0003-4819-102-2-218

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN： 0003-4819            Impact factor:   25.391


  8 in total

1.  High dose folinic acid/etoposide/5-fluorouracil in advanced gastric cancer--a phase II study in elderly patients or patients with cardiac risk.

Authors:  H Wilke; P Preusser; U Fink; W Achterrath; L Lenaz; M Stahl; C Schober; H Link; H J Meyer; B Lucke
Journal:  Invest New Drugs       Date:  1990-02       Impact factor: 3.850

2.  Age-stratified phase I trial of a combination of bortezomib, gemcitabine, and liposomal doxorubicin in patients with advanced malignancies.

Authors:  G S Falchook; M Duvic; D S Hong; J Wheler; A Naing; J Lim; R Kurzrock
Journal:  Cancer Chemother Pharmacol       Date:  2011-12-29       Impact factor: 3.333

Review 3.  [Radiotherapy of the elderly patient. Radiotherapy tolerance and results in older patients].

Authors:  H Geinitz; F B Zimmermann; M Molls
Journal:  Strahlenther Onkol       Date:  1999-03       Impact factor: 3.621

4.  Stress- and aging-associated modulation of macrophage functions.

Authors:  Takako Kizaki; Kenji Suzuki; Tomomi Ookawara; Tetsuya Izawa; Daizoh Saitoh; Shuji Oh-Ishi; Keiichiro Suzuki; Shukoh Haga; Hideki Ohno
Journal:  Environ Health Prev Med       Date:  2002-01       Impact factor: 3.674

Review 5.  Problems in the use of anticancer drugs in the elderly.

Authors:  J E Phister; S G Jue; B J Cusack
Journal:  Drugs       Date:  1989-04       Impact factor: 9.546

6.  Cancer chemotherapy in the elderly: a series of 51 patients aged greater than 70 years.

Authors:  Y Bécouarn; B N Bui; R Brunet; A Ravaud
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

7.  An increase in basal glucocorticoid concentration with age induces suppressor macrophages with high-density Fc gamma RII/III.

Authors:  T Kizaki; T Ookawara; S Oh-Ishi; Y Itoh; K Iwabuchi; K Onoé; N K Day; R A Good; H Ohno
Journal:  Immunology       Date:  1998-03       Impact factor: 7.397

8.  Intensity modulated radiotherapy for elderly bladder cancer patients.

Authors:  Chen-Hsi Hsieh; Shiu-Dong Chung; Pei-Hui Chan; Siu-Kai Lai; Hsiao-Chun Chang; Chi-Huang Hsiao; Le-Jung Wu; Ngot-Swan Chong; Yu-Jen Chen; Li-Ying Wang; Yen-Ping Hsieh; Pei-Wei Shueng
Journal:  Radiat Oncol       Date:  2011-06-16       Impact factor: 3.481
  8 in total

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