True renin in human pituitary tissue.

Readily detectable levels of renin activity were demonstrated in human pituitary tissues. This activity was inhibited by specific antibody raised against human renal renin, indicating that it was not due to the nonspecific action of proteases. It shared some biochemical features with well-known kidney renin, such as molecular weight, optimum pH, and the presence of trypsin-activatable inactive renin. These results suggest that true renin exists in human pituitary tissue.