Literature DB >> 3880046

Lipid microspheres as novel drug carriers.

Y Mizushima1.   

Abstract

SUMMARY: Lipid microsphere preparations of corticosteroid, non-steroid anti-inflammatory drugs and prostaglandin E1 (PGE1) all showed more potent activity than the free drugs. Lipo-PGE1 in particular was significantly more active than free PGE1 at about one-tenth the dose of free PGE1. A large mass of data obtained in studies of liposomes suggest many applications for the lipid microsphere, which is considered to be a very promising carrier in drug delivery systems.

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Year:  1985        PMID： 3880046

Source DB:  PubMed          Journal:  Drugs Exp Clin Res        ISSN： 0378-6501


  10 in total

1.  Influence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cell monolayers.

Authors:  F C Mooren; A Berthold; W Domschke; J Kreuter
Journal:  Pharm Res       Date:  1998-01       Impact factor: 4.200

2.  A cationic lipid emulsion/DNA complex as a physically stable and serum-resistant gene delivery system.

Authors:  S W Yi; T Y Yune; T W Kim; H Chung; Y W Choi; I C Kwon; E B Lee; S Y Jeong
Journal:  Pharm Res       Date:  2000-03       Impact factor: 4.200

3.  Stable prostacyclin improves postischaemic microcirculatory changes in hypertensive rats.

Authors:  K Shima; H Umezawa; H Chigasaki; S Okuyama; H Araki
Journal:  Acta Neurochir (Wien)       Date:  1995       Impact factor: 2.216

4.  The in vitro characterization and biostability of 99mTc-dextran and its accumulation within the inflamed paws of adjuvant-induced arthritic rats.

Authors:  I W Kellaway; L Seale; P S Spencer
Journal:  Pharm Res       Date:  1995-04       Impact factor: 4.200

5.  Determination of the pH-dependent phase distribution of prostaglandin E1 in a lipid emulsion by ultrafiltration.

Authors:  D L Teagarden; B D Anderson; W J Petre
Journal:  Pharm Res       Date:  1988-08       Impact factor: 4.200

6.  Dehydration kinetics of prostaglandin E1 in a lipid emulsion.

Authors:  D L Teagarden; B D Anderson; W J Petre
Journal:  Pharm Res       Date:  1989-03       Impact factor: 4.200

7.  Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.

Authors:  Tsutomu Ishihara; Miho Takeda; Haruka Sakamoto; Ayumi Kimoto; Chisa Kobayashi; Naoko Takasaki; Kanae Yuki; Ken-ichiro Tanaka; Mitsuko Takenaga; Rie Igarashi; Taishi Maeda; Naoki Yamakawa; Yoshinari Okamoto; Masami Otsuka; Tatsuhiro Ishida; Hiroshi Kiwada; Yutaka Mizushima; Tohru Mizushima
Journal:  Pharm Res       Date:  2009-07-25       Impact factor: 4.200

8.  Synthesis of prostaglandin E(1) phosphate derivatives and their encapsulation in biodegradable nanoparticles.

Authors:  Miho Takeda; Taishi Maeda; Tsutomu Ishihara; Haruka Sakamoto; Kanae Yuki; Naoko Takasaki; Fumihiro Nishimura; Takeshi Yamashita; Ken-Ichiro Tanaka; Mitsuko Takenaga; Rie Igarashi; Megumu Higaki; Naoki Yamakawa; Yoshinari Okamoto; Hisao Ogawa; Masami Otsuka; Yutaka Mizushima; Tohru Mizushima
Journal:  Pharm Res       Date:  2009-05-05       Impact factor: 4.200

9.  Activated CD4+ T cells preferentially take up lipid microspheres, but resting cells do not.

Authors:  K Suzuki
Journal:  Clin Exp Immunol       Date:  1995-03       Impact factor: 4.330

10.  Enhanced antitumor activity and reduced toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea administered in lipid microspheres to tumor-bearing mice.

Authors:  M Takenaga; R Igarashi; H Tsuji; Y Mizushima
Journal:  Jpn J Cancer Res       Date:  1993-10
  10 in total

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