Literature DB >> 3878796

Haemophilus influenzae induces a potentiated increase in guinea-pig pulmonary resistance to histamine.

G Folkerts, F P Nijkamp.   

Abstract

The human respiratory pathogen Haemophilus influenzae (H.i.) induced bronchial hyperreactivity to histamine (1.0-8.0 micrograms/100 g b.w. i.v.) in vivo in anaesthetized spontaneously breathing guinea-pigs. This hyperreactivity was caused by a potentiated increase in pulmonary resistance. Decreases in dynamic compliance did not differ. Atropine prevented the potentiation at 1.0 and 2.0 micrograms histamine/100 g b.w. These results show that H.i. induces bronchial hyperreactivity in vivo which is mediated by direct and reflex effects of histamine in the central airways.

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Year:  1985        PMID： 3878796     DOI： 10.1016/0014-2999(85)90329-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Haemophilus influenzae-induced decreases in lung beta-adrenoceptor function and number coincide with decreases in spleen noradrenaline.

Authors:  F Engels; G Folkerts; D van Heuven-Nolsen; F P Nijkamp
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-09       Impact factor: 3.000

2.  Inflammatory reactions in the respiratory airways of the guinea pig do not necessarily induce bronchial hyperreactivity.

Authors:  G Folkerts; P A Henricks; F P Nijkamp
Journal:  Agents Actions       Date:  1988-02

3.  Suppression of PAF-induced bronchoconstriction in the guinea-pig by oxatomide: mechanism of action.

Authors:  F P Nijkamp; G Folkerts; J R Beetens; F De Clerck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000

4.  Effects of anterior hypothalamic lesions and sham-operations on bacterial endotoxin-induced non-specific airway hyperreactivity in vivo and in vitro.

Authors:  A J Van Oosterhout; F M Woutersen-van Nijnanten; G Folkerts; F P Nijkamp
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

5.  Functional characterization of muscarinic receptors in murine airways.

Authors:  J Garssen; H Van Loveren; C M Gierveld; H Van der Vliet; F P Nijkamp
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

6.  Endotoxin-induced hyperreactivity of the guinea-pig isolated trachea coincides with decreased prostaglandin E2 production by the epithelial layer.

Authors:  G Folkerts; F Engels; F P Nijkamp
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739
  6 in total

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