Literature DB >> 3878238

Impaired release of a T-cell specific suppressor factor in rheumatoid arthritis.

C Lau, S Budz-Tymkewycz, M Ramsden, P Lee, E C Keystone.   

Abstract

Peripheral blood T cells from patients with rheumatoid arthritis (RA) and scleroderma (PSS) were assessed for their ability to release T-cell-specific suppressor activity (TRSA) upon incubation with a suppressor activating factor (SAF) derived from a human lymphoblastoid cell line (CEM). T cells from 11/20 (55%) RA patients exhibited impaired TRSA release in contrast to 1/12 (8%) of PSS patients. RA patients demonstrating impaired TRSA release exhibited more active arthritis than patients demonstrating normal TRSA release.

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Year:  1985        PMID： 3878238      PMCID： PMC1577274     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  6 in total

1.  A mutant human T-cell line producing immunosuppressive factor(s).

Authors:  C Y Lau; S Budz-Tymkewycz; E Y Wang; A Ishaque
Journal:  Cell Immunol       Date:  1984-08       Impact factor: 4.868

2.  Analysis of suppressor T cell function in patients with rheumatoid arthritis: defects in production of and responsiveness to concanavalin A-induced suppressor T cells.

Authors:  T Sakane; S Takada; Y Murakawa; H Kotani; M Honda; Y Ueda
Journal:  J Immunol       Date:  1982-11       Impact factor: 5.422

3.  Suppressor T cell dysfunction and anti-suppressor cell antibody in active early rheumatoid arthritis.

Authors:  N I Abdou; H B Lindsley; L S Racela; E Pascual; K M Hassanein
Journal:  J Rheumatol       Date:  1981 Jan-Feb       Impact factor: 4.666

4.  Impaired antigen-specific suppressor cell activity in patients with rheumatoid arthritis.

Authors:  E C Keystone; D D Gladman; R Buchanan; D Cane; L Poplonski
Journal:  Arthritis Rheum       Date:  1980-11

5.  Mechanism of action of a suppressor-activating factor (SAF) produced by a human T cell line.

Authors:  C Y Lau; E Y Wang; D Li; S Budz-Tymkewycz; V Visconti; A Ishaque
Journal:  J Immunol       Date:  1985-05       Impact factor: 5.422

6.  Concanavalin A-induced suppressor cell activity and in vitro immunoglobulin secretion in rheumatoid arthritis: correlation with clinical and immunological parameters.

Authors:  J S Smolen; G Lanzer; O Scherak; E J Menzel; W R Mayr; C Steffen; W Knapp
Journal:  Rheumatol Int       Date:  1981       Impact factor: 2.631
  6 in total
  2 in total

Review 1.  Human nonspecific suppressive lymphokines.

Authors:  M T Halpern
Journal:  J Clin Immunol       Date:  1991-01       Impact factor: 8.317

2.  Origin of defective T lymphocyte-suppressor activating factor interaction in patients with rheumatoid arthritis.

Authors:  E C Keystone; S Budz-Tymkewycz; M Toews; C Lau
Journal:  Clin Exp Immunol       Date:  1987-07       Impact factor: 4.330
  2 in total

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