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Literature DB >> 3877936

Enhancement of antibody response by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised against a private rabbit idiotype.

Abstract

The role of splenic lymphoid dendritic cells (DC) and macrophages (M phi) from mice in induction of immune responses in vivo has been investigated. Varying numbers of purified DC and M phi pulsed in vitro with tobacco mosaic virus (TMV) or with rabbit antiidiotypic antibodies (Ab2) directed against a private rabbit anti-TMV idiotype were injected back into syngeneic mice. In both systems, DC appeared to strongly enhance the primary and secondary responses to the virus. Optimal responses were obtained with 5 X 10(4) purified DC carrying TMV or rabbit Ab2. In contrast, M phi were less efficient by a factor of at least 100. These results show the potency of lymphoid DC as inducing cells in T-dependent antibody responses in vivo.

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Year: 1985 PMID： 3877936 PMCID： PMC391460 DOI： 10.1073/pnas.82.23.8149

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

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Authors: J Urbain; M Wikler; J D Franssen; C Collignon
Journal: Proc Natl Acad Sci U S A Date: 1977-11 Impact factor: 11.205

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Journal: Ann Immunol (Paris) Date: 1979 Mar-Apr

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Authors: R W Chesnut; H M Grey
Journal: Crit Rev Immunol Date: 1985 Impact factor: 2.214

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Authors: R M Steinman; M D Witmer
Journal: Proc Natl Acad Sci U S A Date: 1978-10 Impact factor: 11.205

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Authors: C Bona; W E Paul
Journal: J Exp Med Date: 1979-03-01 Impact factor: 14.307

6. Idiotypic regulation of the immune system. Common idiotypic specificities between idiotypes and antibodies raised against anti-idiotypic antibodies in rabbits.

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Journal: J Exp Med Date: 1979-07-01 Impact factor: 14.307

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Authors: W Ptak; D Rozycka; P W Askenase; R K Gershon
Journal: J Exp Med Date: 1980-02-01 Impact factor: 14.307

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Authors: R M Steinman; G Kaplan; M D Witmer; Z A Cohn
Journal: J Exp Med Date: 1979-01-01 Impact factor: 14.307

3. Interaction of human immunodeficiency virus type 1, human T-cell leukemia/lymphoma virus type I (HTLV-I), and HTLV-II with in vitro-generated dendritic cells.

Authors: D Zucker-Franklin; M Fraig; G Grusky
Journal: Clin Diagn Lab Immunol Date: 1995-05

4. Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

Authors: T Sornasse; V Flamand; G De Becker; H Bazin; F Tielemans; K Thielemans; J Urbain; O Leo; M Moser
Journal: J Exp Med Date: 1992-01-01 Impact factor: 14.307

4 in total