Literature DB >> 3877890

Cerebral uptake and retention of 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO).

R A Holmes, S B Chaplin, K G Royston, T J Hoffman, W A Volkert, D P Nowotnik, L R Canning, S A Cumming, R C Harrison, B Higley.   

Abstract

A new radiopharmaceutical, 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO) is described. This agent displays considerable promise for imaging cerebral blood flow. In studies in rats and one human volunteer, 99Tcm-HM-PAO demonstrates good brain uptake, prolonged retention of activity in the brain, and slow regional redistribution. These properties suggest that this new radiopharmaceutical is ideal for single photon emission tomographic (SPECT) imaging of cerebral blood flow.

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Year:  1985        PMID： 3877890     DOI： 10.1097/00006231-198508000-00003

Source DB:  PubMed          Journal:  Nucl Med Commun        ISSN： 0143-3636            Impact factor:   1.690


  14 in total

Review 1.  Nuclear medicine at the crossroads.

Authors:  H W Strauss
Journal:  Eur J Nucl Med       Date:  1996-06

2.  The development of an epileptogenic focus. A case study with 99mTc-HMPAO SPECT.

Authors:  D Dressler; E Voth; M Feldmann; T Henze; K Felgenhauer
Journal:  J Neurol       Date:  1989-07       Impact factor: 4.849

3.  Single photon emission computed tomography with 99mTc HM-PAO in the study of focal epilepsy.

Authors:  E Grasso; L Ambrogio; A Cognazzo; P C Gerbino-Promis; P Zagnoni; G F Camuzzini; A Papaleo; F Acchiardi; G Perno
Journal:  Ital J Neurol Sci       Date:  1989-04

4.  Does the washout phenomenon of Tc-99m HM-PAO correlate to the "filling-in" phenomenon of I-123 IMP with brain SPECT?

Authors:  K Hayashida; T Nishimura; S Imakita; T Uehara
Journal:  Neuroradiology       Date:  1990       Impact factor: 2.804

5.  Determination of cerebral perfusion by means of planar brain scintigraphy and 99mTc-HMPAO in brain death, persistent vegetative state and severe coma.

Authors:  H P Schlake; I G Böttger; K H Grotemeyer; I W Husstedt; W Brandau; O Schober
Journal:  Intensive Care Med       Date:  1992       Impact factor: 17.440

6.  Perfusion mapping with Tc-HMPAO in cerebral haematomas.

Authors:  M Rousseaux; M Steinling; D Huglo; A Mazingue; P Barbaste
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-12       Impact factor: 10.154

7.  Visualization of posture-dependent cerebral blood flow in a patient with Takayasu's disease by means of 99mTc-HMPAO brain single photon emission tomography.

Authors:  K Hayashida; T Nishimura; Y Hirose; T Kaminaga; S Imakita; T Uehara
Journal:  Eur J Nucl Med       Date:  1992

8.  Quantitative assessment of cerebral blood flow using technetium-99m-hexamethyl-propyleneamine oxime: Part I, Design of a mathematical model.

Authors:  H Matsuda; H Oba; H Terada; S Tsuji; H Sumiya; K Shiba; H Seki; K Imai; H Mori; K Hisada
Journal:  Ann Nucl Med       Date:  1988-05       Impact factor: 2.668

9.  Evaluation of brain SPECT in the diagnosis and prognosis of the normal pressure hydrocephalus syndrome.

Authors:  J M Granado; F Diaz; R Alday
Journal:  Acta Neurochir (Wien)       Date:  1991       Impact factor: 2.216

10.  Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.

Authors:  D Neary; J S Snowden; R A Shields; A W Burjan; B Northen; N MacDermott; M C Prescott; H J Testa
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-09       Impact factor: 10.154
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