Literature DB >> 3877741

Chronic relapsing experimental allergic encephalomyelitis in the Lewis rat.

C Feurer, D E Prentice, S Cammisuli.   

Abstract

Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) was induced in rats with an emulsion of guinea-pig spinal cord tissue (GPSC) in complete Freund's adjuvant (CFA) enriched with Mycobacterium tuberculosis H37RA (Tbc). 78% of the sensitized rats developed a CR-EAE showing 2 to 3 clinical relapses during the first 40 days. After 60-80 days, approximately half of the rats with CR-EAE had a further relapse which was followed by complete recovery in only 35% of the cases. The remaining 65% of these animals showed a progressive state of the disease, characterized by paralysis or severe motor deficit, eventually leading to death. CR-EAE in rats showed some similarities to multiple sclerosis in man (MS) and it may be a useful model for the study of this disease.

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Year:  1985        PMID： 3877741     DOI： 10.1016/0165-5728(85)90006-2

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  10 in total

1.  Effect of physical exercise on adoptive experimental auto-immune encephalomyelitis in rats.

Authors:  C Le Page; S Bourdoulous; E Béraud; P O Couraud; M Rieu; A Ferry
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1996

2.  The neuropathology of chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat by inoculation with whole spinal cord and treatment with cyclosporin A.

Authors:  M P Pender; G P Stanley; G Yoong; K B Nguyen
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

3.  Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.

Authors:  Eric J Tarcha; Victor Chi; Ernesto J Muñoz-Elías; David Bailey; Luz M Londono; Sanjeev K Upadhyay; Kayla Norton; Amy Banks; Indra Tjong; Hai Nguyen; Xueyou Hu; Greg W Ruppert; Scott E Boley; Richard Slauter; James Sams; Brian Knapp; Dustin Kentala; Zachary Hansen; Michael W Pennington; Christine Beeton; K George Chandy; Shawn P Iadonato
Journal:  J Pharmacol Exp Ther       Date:  2012-05-25       Impact factor: 4.030

4.  15-Deoxyspergualin (15-DOS) for therapy in an animal model of multiple sclerosis (MS): disease modifying activity on acute and chronic relapsing experimental allergic encephalomyelitis (EAE).

Authors:  H U Schorlemmer; F R Seiler
Journal:  Agents Actions       Date:  1991-09

5.  Mechanism of action and efficacy of RX-111, a thieno[2,3-c]pyridine derivative and small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), in delayed-type hypersensitivity, TNBS-induced colitis and experimental autoimmune encephalomyelitis.

Authors:  Nicholas Harris; Juraj Koppel; Ferenc Zsila; Stefan Juhas; Gabriela Il'kova; Faina Yurgenzon Kogan; Orly Lahmy; Gizi Wildbaum; Nathan Karin; Regina Zhuk; Paul Gregor
Journal:  Inflamm Res       Date:  2016-01-21       Impact factor: 4.575

6.  Preventive and therapeutic effects of cyclosporin and valine2-dihydro-cyclosporin in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat.

Authors:  C Feurer; L H Chow; J F Borel
Journal:  Immunology       Date:  1988-02       Impact factor: 7.397

7.  Oxidative Stress and Lymphocyte Alterations in Chronic Relapsing Experimental Allergic Encephalomyelitis in the Rat Hippocampus and Protective Effects of an Ethanolamine Phosphate Salt.

Authors:  Aranzazu Perianes-Cachero; María V T Lobo; Alberto M Hernández-Pinto; Rebeca Busto; Miguel Angel Lasunción-Ripa; Eduardo Arilla-Ferreiro; Lilian Puebla-Jiménez
Journal:  Mol Neurobiol       Date:  2019-09-10       Impact factor: 5.590

8.  In vivo and in vitro models of demyelinating diseases. XXIV. The infectious process in cyclosporin A treated Wistar Lewis rats inoculated with JHM virus.

Authors:  M J Zimmer; S Dales
Journal:  Microb Pathog       Date:  1989-01       Impact factor: 3.738

Review 9.  In vitro and in vivo pharmacological models to assess demyelination and remyelination.

Authors:  Jean E Merrill
Journal:  Neuropsychopharmacology       Date:  2008-09-17       Impact factor: 7.853

10.  Cerebral biochemical pathways in experimental autoimmune encephalomyelitis and adjuvant arthritis: a comparative metabolomic study.

Authors:  Norbert W Lutz; Carla Fernandez; Jean-François Pellissier; Patrick J Cozzone; Evelyne Béraud
Journal:  PLoS One       Date:  2013-02-14       Impact factor: 3.240
  10 in total

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