Literature DB >> 3877508

Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA.

T Yamamoto, Y Nakamura, J Nishide, M Emi, M Ogawa, T Mori, K Matsubara.   

Abstract

We have isolated and sequenced a cDNA clone coding for the human pancreatic secretory trypsin inhibitor (PSTI) from a human pancreatic cDNA library. The predicted product consists of 79 amino acids, and contains no apparent functional polypeptide other than PSTI. Southern blot analysis suggests that there is one copy of PSTI gene per haploid genome. This gene seems to be expressed not only in pancreas, but also in gastric mucosa, since a Northern blot analysis demonstrated the presence of a poly(A) RNA of the same size as in the pancreas. A comparison of sequences between human PSTI mRNA and mouse epidermal growth factor (EGF) mRNA revealed a high homology, suggesting that they share a common ancestral DNA sequence.

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Year:  1985        PMID： 3877508     DOI： 10.1016/0006-291x(85)91176-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

1.  Production and secretion of pancreatic secretory trypsin inhibitor in normal human small intestine.

Authors:  H Bohe; M Bohe; E Lundberg; A Polling; K Ohlsson
Journal:  J Gastroenterol       Date:  1997-10       Impact factor: 7.527

2.  Two Microplitis demolitor polydnavirus mRNAs expressed in hemocytes of Pseudoplusia includens contain a common cysteine-rich domain.

Authors:  M R Strand; R A Witherell; D Trudeau
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

3.  Isolation and characterization of a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor: influence on insulin secretion.

Authors:  B Agerberth; J Söderling-Barros; H Jörnvall; Z W Chen; C G Ostenson; S Efendić; V Mutt
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

4.  Distribution and expression of pancreatic secretory trypsin inhibitor and its possible role in epithelial restitution.

Authors:  T Marchbank; R Chinery; A M Hanby; R Poulsom; G Elia; R J Playford
Journal:  Am J Pathol       Date:  1996-03       Impact factor: 4.307

5.  Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis.

Authors:  C Férec; O Raguénès; R Salomon; C Roche; J P Bernard; M Guillot; I Quéré; C Faure; B Mercier; M P Audrézet; P J Guillausseau; C Dupont; A Munnich; J D Bignon; L Le Bodic
Journal:  J Med Genet       Date:  1999-03       Impact factor: 6.318

Review 6.  Pathophysiology of chronic pancreatitis.

Authors:  Christina Brock; Lecia Møller Nielsen; Dina Lelic; Asbjørn Mohr Drewes
Journal:  World J Gastroenterol       Date:  2013-11-14       Impact factor: 5.742

7.  Pancreatic secretory trypsin inhibitor in gastrointestinal mucosa and gastric juice.

Authors:  T C Freeman; R J Playford; C Quinn; K Beardshall; L Poulter; J Young; J Calam
Journal:  Gut       Date:  1990-11       Impact factor: 23.059

8.  Overexpression of pancreatic secretory trypsin inhibitor in pancreatic cancer. Evaluation of its biological function as a growth factor.

Authors:  Y Ohmachi; A Murata; N Matsuura; T Yasuda; K Uda; T Mori
Journal:  Int J Pancreatol       Date:  1994-02

9.  Primary structure of the human follistatin precursor and its genomic organization.

Authors:  S Shimasaki; M Koga; F Esch; K Cooksey; M Mercado; A Koba; N Ueno; S Y Ying; N Ling; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

Review 10.  Review of Diagnostic Biomarkers in Autoimmune Pancreatitis: Where Are We Now?

Authors:  Masataka Yokode; Masahiro Shiokawa; Yuzo Kodama
Journal:  Diagnostics (Basel)       Date:  2021-04-25
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