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Literature DB >> 3877222

Production, characteristics and mode of action of hemopoietic growth inhibitors in myeloid leukemias.

Abstract

The best characterized hemopoietic growth inhibitors in myeloid leukemias are leukemia associated inhibitor (LAI) and leukemia inhibitory activity (LIA). Both are normal cell products overproduced in leukemia. LIA is identical with acid isoferritins and LAI is not identical with LIA. They act in different ways to inhibit normal stem cell growth. The overproduction of these putative normal regulators may explain the suppression of normal hemopoiesis typical of myeloid leukemias. Modulation of the production and the action of LAI and LIA may have potential therapeutic value in leukemia.

Entities: Disease

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Year: 1985 PMID： 3877222 DOI： 10.1007/bf02934773

Source DB: PubMed Journal: Med Oncol Tumor Pharmacother ISSN： 0736-0118

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References

29 in total

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Production, characteristics and mode of action of hemopoietic growth inhibitors in myeloid leukemias.

1. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.

2. Inhibitor of hematopoietic cell proliferation derived from a human leukemic cell line.

3. The growth of mouse bone marrow cells in vitro.

4. Colony growth of human leukemic peripheral blood cells in vitro.

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