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Literature DB >> 3877139

An arthritogenic lymphokine in the rat.

S M Helfgott, R Dynesius-Trentham, E Brahn, D E Trentham.

Abstract

A type II collagen-specific arthritogenic lymphokine has been identified in the rat. Arthritogenic factor (AF) is a 65 kD protein generated in vitro by T cells from rats with collagen arthritis, and it induces an erosive, proliferative synovitis when injected into the knee joint of syngeneic naive recipients. Complement does not appear to be required. These data identify a potential T cell-mediated effector mechanism in this model, and suggest that AF may function in other inflammatory synovial diseases.

Entities: Disease Species

Mesh：

Substances：
Lymphokines
Collagen

Year: 1985 PMID： 3877139 PMCID： PMC2187934 DOI： 10.1084/jem.162.5.1531

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

44 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma.

Authors: J Travis; J Bowen; D Tewksbury; D Johnson; R Pannell
Journal: Biochem J Date: 1976-08-01 Impact factor: 3.857

3. Passive transfer by cells of type II collagen-induced arthritis in rats.

Authors: D E Trentham; R A Dynesius; J R David
Journal: J Clin Invest Date: 1978-08 Impact factor: 14.808

4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

5. Experimental arthritis produced by injection of mediators of delayed hypersensitivity.

Authors: M Andreis; P Stastny; M Ziff
Journal: Arthritis Rheum Date: 1974 Sep-Oct

6. Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors: G Mancini; A O Carbonara; J F Heremans
Journal: Immunochemistry Date: 1965-09

7. Lymphokines in rheumatoid synovitis.

Authors: P Stastny; M Rosenthal; M Andreis; D Cooke; M Ziff
Journal: Ann N Y Acad Sci Date: 1975-06-13 Impact factor: 5.691

8. Cellular sensitivity to collagen in rheumatoid arthritis.

Authors: D E Trentham; R A Dynesius; R E Rocklin; J R David
Journal: N Engl J Med Date: 1978-08-17 Impact factor: 91.245

9. Collagen-induced arthritis in rats. Evaluation of early immunologic events.

Authors: J M Stuart; M A Cremer; A H Kang; A S Townes
Journal: Arthritis Rheum Date: 1979-12

10. Autoimmunity to type II collagen an experimental model of arthritis.

Authors: D E Trentham; A S Townes; A H Kang
Journal: J Exp Med Date: 1977-09-01 Impact factor: 14.307

9 in total

1. Immunotherapy of experimental arthritis. Analysis of the articular cartilage of mice suppressed for collagen-induced arthritis by a T-cell hybridoma.

Authors: T F Kresina
Journal: Am J Pathol Date: 1987-11 Impact factor: 4.307

An arthritogenic lymphokine in the rat.

1. Protein measurement with the Folin phenol reagent.

2. Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma.

3. Passive transfer by cells of type II collagen-induced arthritis in rats.

4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

5. Experimental arthritis produced by injection of mediators of delayed hypersensitivity.

6. Immunochemical quantitation of antigens by single radial immunodiffusion.

7. Lymphokines in rheumatoid synovitis.

8. Cellular sensitivity to collagen in rheumatoid arthritis.

9. Collagen-induced arthritis in rats. Evaluation of early immunologic events.

10. Autoimmunity to type II collagen an experimental model of arthritis.

1. Immunotherapy of experimental arthritis. Analysis of the articular cartilage of mice suppressed for collagen-induced arthritis by a T-cell hybridoma.

2. Induction of erosive arthritis in mice after passive transfer of anti-type II collagen antibodies.

3. Role of T lymphocytes in murine collagen induced arthritis.

4. Activation pathways of synovial T lymphocytes. Expression and function of the UM4D4/CDw60 antigen.

5. Immunotherapy of collagen-induced arthritis by a T-cell antiproliferative molecule.

6. Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis.

7. Flare-up of experimental arthritis in mice with murine recombinant IL-1.

8. Partial characterization of a fibroblast-stimulating factor produced by cloned murine T lymphocytes.

9. Tolerogenic activity of polymerized type II collagen in preventing collagen-induced arthritis in rats.