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Literature DB >> 3876983

Two B-cell subpopulations identified by flow cytometry.

Abstract

Ig+ spleen cells were analysed by light scatter analysis on a flow cytometer and two distinct subpopulations were identified. The large Ig+ cells (10-11 micron in diameter) were found in spleen and bone marrow, whereas the small Ig+ cells (7-8 micron in diameter) were found in all lymphoid tissues. Of the total Ig+ splenic lymphocytes, 40-60% were large Ig+ cells and had surface IgM, Ia and Fc gamma receptors. The large Ig+ cells were highly enriched for responsiveness to the B-cell mitogens, anti-Ig, Nocardia water-soluble mitogen and LPS, whereas the small Ig+ splenic cells had little or no responsiveness to these mitogens.

Entities: Chemical Disease

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Year: 1985 PMID： 3876983 PMCID： PMC1453683

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

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References

25 in total

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Two B-cell subpopulations identified by flow cytometry.

Review 1. Thymus-independent B-cell induction and paralysis.

2. Rabbit lymphocyte subpopulations. I. Separation of Ig+ and Ig- cells and their interaction in cultures stimulated by mitogens.

3. B Cell heterogeneity - difference in the size of B lymphocytes responding to T dependent and T independent antigens.

4. Volume, adherence properties, membrane antigens and mitogen responsiveness of rabbit lymphoid cell subpopulations.

5. Regulation of antibody response in vitro. VI. Carrier-specific helper cells for IgG and IgE antibody response.

6. Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

7. Surface immunoglobulin on rabbit lymphoid cells. II. Ultrastructural distribution of b4 allotypic determinants and morphology of spleen lymphocytes.

Review 8. Regulation of growth and proliferation in B cell subpopulations.

9. Role of the thymus in directing the development of a subset of B lymphocytes.

10. Immunological memory in mice. I. Physical separation and partial characterization of memory cells for different immunoglobulin classes from each other and from antibody-producing cells.