| Literature DB >> 3876434 |
P Dyer, D M Grennan, W Dodds, K Walton, A Read, P Klimiuk, R Clague, R Harris.
Abstract
Properdin factor B (Bf) phenotyping was carried out in 392 patients with rheumatoid arthritis (RA) and in 360 controls. In RA there were increased frequencies of both the Bf*S gene (83 vs 78%; pc = 0.0003) and the BfSS genotype 73 vs 61%; pc = 0.0002) and reduced frequencies of the Bf*F1 gene (0.5 vs 2.2%; pc = 0.03) and the BfFS genotype (20 vs 29%; pc = 0.0007). The frequencies of Bf*S in DR4 positive and DR4 negative RA were similar so that the findings were not accounted for by linkage disequilibrium between DR4 and Bf*S.Entities:
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Year: 1985 PMID： 3876434
Source DB: PubMed Journal: J Rheumatol ISSN： 0315-162X Impact factor: 4.666