| Literature DB >> 387629 |
M Frankenberg-Schwager, D Frankenberg, D Blöcher, C Adamczyk.
Abstract
Survival and induction of DNA double-strand breaks were studied in cells of Saccharomyces cerevisiae irradiated under oxic or anoxic conditions with 30 MeV electrons. A linear relationship between DNA double-strand breakage and dose was found in both cases. The o.e.r.-value for colony forming ability was found to be 1.9 +/- 0.2, whereas the o.e.r.-value for DNA double-strand breakage was 3.0 +/- 0.1. These results are not inconsistent with the idea that DNA double-strand breaks are involved in killing of yeast cells. The frequency of induction of DNA double-strand breaks was found to be 0.74 x 10(-11) double-strand breaks per g/mol per Gy when cells were irradiated under oxygen and 0.24 x 10(-11) double-strand breaks per g/mol per Gy under nitrogen.Entities:
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Year: 1979 PMID： 387629 DOI： 10.1080/09553007914551031
Source DB: PubMed Journal: Int J Radiat Biol Relat Stud Phys Chem Med ISSN： 0020-7616