Literature DB >> 3875766

Intracellular human IL-1: a precursor for the secreted monokine.

C G Sahasrabuddhe, C Dinarello, B Martin, A L Maizel.   

Abstract

An intracellular monocyte derived protein possessing interleukin 1 (IL-1) activity has been compared with the secreted from of IL-1. Our results indicated that this intracellular IL-1 had an apparent size greater than that of extracellular IL-1. Data are presented to show that a rabbit heterotypic antiserum prepared against epitopes on the secreted form of human IL-1 blocked the biologic activity of intracellular IL-1 in a dose dependent manner. Intracellular IL-1 had a mass of 30-40 kDa as determined by gel filtration using sephacryl-200 gel.

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Year:  1985        PMID： 3875766

Source DB:  PubMed          Journal:  Lymphokine Res        ISSN： 0277-6766


  4 in total

1.  Epidermis and lymphocyte interactions during a tuberculin skin reaction. I. Increased ETAF/IL-1 like activity, expression of tissue antigens and mixed skin lymphocyte reactivity.

Authors:  C G Larsen; T Ternowitz; F G Larsen; K Thestrup-Pedersen
Journal:  Arch Dermatol Res       Date:  1988       Impact factor: 3.017

2.  Multiple biological activities of human recombinant interleukin 1.

Authors:  C A Dinarello; J G Cannon; J W Mier; H A Bernheim; G LoPreste; D L Lynn; R N Love; A C Webb; P E Auron; R C Reuben
Journal:  J Clin Invest       Date:  1986-06       Impact factor: 14.808

3.  Differential effects of ether lipids on the activity and secretion of interleukin-1 and interleukin-2.

Authors:  R Andreesen; V Giese
Journal:  Lipids       Date:  1987-11       Impact factor: 1.880

4.  Antibodies to interleukin-1 raised with synthetic peptides: identification of external sites and analysis of interleukin-1 synthesis in stimulated human peripheral blood monocytes.

Authors:  R Bomford; E Abdulla; C Hughes-Jenkins; D Simpkin; J Schmidt
Journal:  Immunology       Date:  1987-12       Impact factor: 7.397
  4 in total

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