Literature DB >> 3875626

Interleukin 2 production in whole blood culture: a rapid test of immunity to Francisella tularensis.

R Karttunen, J Ilonen, E Herva.   

Abstract

The measurement of interleukin 2 from antigen-stimulated whole blood culture supernatants was used to detect cell-mediated immunity in subjects sensitized against Francisella tularensis. The amount of interleukin 2 produced differentiated a positive immune reaction sensitively and reliably in a 24-h culture. Whole blood culturing is an easy method for producing interleukin 2.

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Year:  1985        PMID： 3875626      PMCID： PMC268388          DOI： 10.1128/jcm.22.2.318-319.1985

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  7 in total

1.  Lymphokine production by peripheral blood leucocytes: quantitation of T-cell growth factor activity for assessment of immune response capability.

Authors:  H S Warren; R G Pembrey
Journal:  Aust N Z J Med       Date:  1981-10

2.  Detection of HSV-1-induced lymphokine production in human cells by a direct indicator cell addition assay.

Authors:  K A Clouse; F H Bach; C G Orosz
Journal:  J Immunol       Date:  1984-06       Impact factor: 5.422

3.  Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets.

Authors:  R Karttunen; T Nurmi; J Ilonen; H M Surcel
Journal:  Clin Exp Immunol       Date:  1984-02       Impact factor: 4.330

4.  Detection of antigen-specific cellular immune response by the in vitro production of T-cell growth factor.

Authors:  J Ilonen; A Salmi
Journal:  Scand J Immunol       Date:  1981-05       Impact factor: 3.487

5.  A whole-blood lymphocyte stimulation test for the diagnosis of human tularemia.

Authors:  H Syrjälä; E Herva; J Ilonen; K Saukkonen; A Salminen
Journal:  J Infect Dis       Date:  1984-12       Impact factor: 5.226

Review 6.  Cell-mediated immunity against Francisella tularensis after natural infection.

Authors:  P Koskela; E Herva
Journal:  Scand J Infect Dis       Date:  1980

7.  An ELISA-based assay for quantitation of human interleukin 2.

Authors:  L O Gehman; R J Robb
Journal:  J Immunol Methods       Date:  1984-11-16       Impact factor: 2.303
  7 in total
  5 in total

Review 1.  Francisella tularensis--a model for studies of the immune response to intracellular bacteria in man.

Authors:  A Tärnvik; M Eriksson; G Sandström; A Sjöstedt
Journal:  Immunology       Date:  1992-07       Impact factor: 7.397

2.  Kinetics of the immune response associated with tularemia: comparison of an enzyme-linked immunosorbent assay, a tube agglutination test, and a novel whole-blood lymphocyte stimulation test.

Authors:  Henrik Eliasson; Per Olcén; Anders Sjöstedt; Margareta Jurstrand; Erik Bäck; Sören Andersson
Journal:  Clin Vaccine Immunol       Date:  2008-06-18

3.  Interleukin 2 and gamma interferon production, interleukin 2 receptor expression, and DNA synthesis induced by tularemia antigen in vitro after natural infection or vaccination.

Authors:  R Karttunen; G Andersson; H P Ekre; K Juutinen; H M Surcel; H Syrjälä; E Herva
Journal:  J Clin Microbiol       Date:  1987-06       Impact factor: 5.948

4.  Several membrane polypeptides of the live vaccine strain Francisella tularensis LVS stimulate T cells from naturally infected individuals.

Authors:  A Sjöstedt; G Sandström; A Tärnvik
Journal:  J Clin Microbiol       Date:  1990-01       Impact factor: 5.948

5.  Francisella tularensis-induced in vitro gamma interferon, tumor necrosis factor alpha, and interleukin 2 responses appear within 2 weeks of tularemia vaccination in human beings.

Authors:  R Karttunen; H M Surcel; G Andersson; H P Ekre; E Herva
Journal:  J Clin Microbiol       Date:  1991-04       Impact factor: 5.948
  5 in total

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