| Literature DB >> 3874833 |
E Ehrin, L Farde, T de Paulis, L Eriksson, T Greitz, P Johnström, J E Litton, J L Nilsson, G Sedvall, S Stone-Elander.
Abstract
A new dopamine receptor antagonist, Raclopride (S-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)]methyl-2-hydroxy- 6-methoxybenzamide, FLA 870) (1), has been labelled using [11C]ethyl iodide for alkylation of the nitrogen of the pyrrolidine ring in the corresponding secondary amine (5). The synthesis of 5 and an efficient method for the preparation of [11C]ethyl iodide are described. The 11C-labelled FLA 870 (1) was purified by HPLC and then used in positron emission tomography to visualize the dopamine receptor-rich areas of the monkey brain. The images obtained show selective accumulation of FLA 870 in striatum and a 10-fold separation between the binding to caudate vs cerebellum.Entities:
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Year: 1985 PMID： 3874833 DOI： 10.1016/0020-708x(85)90083-3
Source DB: PubMed Journal: Int J Appl Radiat Isot ISSN： 0020-708X