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Literature DB >> 3874261

Induction of influenza A virus cross-reactive cytotoxic T cells by a nucleoprotein/haemagglutinin preparation.

Abstract

An ammonium deoxycholate fraction from bromelain-treated influenza A virus was highly enriched for virus nucleoprotein and contained residual haemagglutinin (NP/HA). The preparation did not contain detectable levels of matrix or neuraminidase proteins and was free of infectious virus. NP/HA effectively primed mice for cytotoxic T cells which lysed syngeneic cells infected with any type A influenza virus. Furthermore, NP/HA generated A-type virus cross-reactive cytotoxic T cells when added in vitro to spleen cells from mice previously primed with infectious influenza A virus. These properties imply that NP/HA has potential as a vaccine for heterotypic influenza A immunity.

Entities: Chemical Gene Species

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Year: 1985 PMID： 3874261 DOI： 10.1099/0022-1317-66-6-1327

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

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Cited

23 in total

1. Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route.

Authors: A M Mowat; A M Donachie; G Reid; O Jarrett
Journal: Immunology Date: 1991-03 Impact factor: 7.397

2. Induction of single and dual cytotoxic T-lymphocyte responses to viral proteins in mice using recombinant hybrid Ty-virus-like particles.

Authors: G T Layton; S J Harris; J Myhan; D West; F Gotch; M Hill-Perkins; J S Cole; N Meyers; S Woodrow; T J French; S E Adams; A J Kingsman
Journal: Immunology Date: 1996-02 Impact factor: 7.397

Review 3. New aspects of vaccine development.

Authors: F Y Liew
Journal: Clin Exp Immunol Date: 1985-11 Impact factor: 4.330

4. Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.

Authors: P M Taylor; B A Askonas
Journal: Immunology Date: 1986-07 Impact factor: 7.397

5. Influenza virus-specific cytotoxic T-cell recognition: stimulation of nucleoprotein-specific clones with intact antigen.

Authors: D C Wraith; A E Vessey
Journal: Immunology Date: 1986-10 Impact factor: 7.397

Induction of influenza A virus cross-reactive cytotoxic T cells by a nucleoprotein/haemagglutinin preparation.

1. Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route.

2. Induction of single and dual cytotoxic T-lymphocyte responses to viral proteins in mice using recombinant hybrid Ty-virus-like particles.

Review 3. New aspects of vaccine development.

4. Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.

5. Influenza virus-specific cytotoxic T-cell recognition: stimulation of nucleoprotein-specific clones with intact antigen.

Review 6. Recognition of influenza virus proteins by cytotoxic T lymphocytes.

7. CD4-positive and CD8-positive cytotoxic T lymphocytes contribute to human papillomavirus type 16 E6 and E7 responses.

8. Low responder MHC alleles for Tc recognition of influenza nucleoprotein.

9. Influenza vaccination in older patients. Immunogenicity, epidemiology and available agents.

Review 10. Development of a universal CTL-based vaccine for influenza.