Literature DB >> 3873495

Anti-IgE autoantibody in patients with atopic dermatitis.

Y Nawata, T Koike, H Hosokawa, H Tomioka, S Yoshida.   

Abstract

The anti-IgE autoantibody in the IgG class was detected in 39/45 (86.7%) patients with atopic dermatitis by using a newly established solid-phase enzyme immunoassay. The epsilon-chain specificity of the anti-IgE autoantibody was confirmed by competitive inhibition by using human IgG, IgA, IgM, IgD, IgE, and heat-denatured IgE protein. Significant correlations were observed between the levels of the anti-IgE autoantibody and the serum IgE. Gel filtration studies indicated that the anti-IgE autoantibody in sera from atopic dermatitis was mainly present in the form of an immune complex with self IgE. The role of the IgE-anti-IgE immune complex and the role of the anti-IgE autoantibody in the modulation of the IgE-mediated immune system in atopic dermatitis are discussed.

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Year:  1985        PMID： 3873495

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  10 in total

Review 1.  Clinical significance of anti-IgE autoantibodies and immune complexes containing IgE.

Authors:  C G Magnusson; S G Johansson
Journal:  Clin Rev Allergy       Date:  1989

2.  Do IgE-IgG complexes occur in the circulation?

Authors:  L Boluda; L Berrens
Journal:  Clin Exp Immunol       Date:  1995-04       Impact factor: 4.330

3.  Induction of an auto-anti-IgE response in rats. III. Inhibition of a specific IgE response.

Authors:  J S Marshall; E B Bell
Journal:  Immunology       Date:  1989-03       Impact factor: 7.397

4.  Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients?

Authors:  E Fiebiger; D Maurer; H Holub; B Reininger; G Hartmann; M Woisetschläger; J P Kinet; G Stingl
Journal:  J Clin Invest       Date:  1995-12       Impact factor: 14.808

5.  Autoantibodies to IgE can induce the release of proinflammatory and vasoactive mediators from human cardiac mast cells.

Authors:  Remo Poto; Vincenzo Patella; Gjada Criscuolo; Gianni Marone; Enrico Coscioni; Gilda Varricchi
Journal:  Clin Exp Med       Date:  2022-07-25       Impact factor: 5.057

6.  IgG Autoantibodies Against IgE from Atopic Dermatitis Can Induce the Release of Cytokines and Proinflammatory Mediators from Basophils and Mast Cells.

Authors:  Remo Poto; Isabella Quinti; Gianni Marone; Maurizio Taglialatela; Amato de Paulis; Vincenzo Casolaro; Gilda Varricchi
Journal:  Front Immunol       Date:  2022-05-31       Impact factor: 8.786

7.  Induction of an auto-anti-IgE response in rats. IV. Effects on mast cell degranulation.

Authors:  G Jaffery; E B Bell; J W Coleman
Journal:  Immunology       Date:  1993-04       Impact factor: 7.397

Review 8.  Autoimmune urticaria.

Authors:  Malcolm Greaves
Journal:  Clin Rev Allergy Immunol       Date:  2002-10       Impact factor: 8.667

9.  Anti-IgE autoantibodies in systemic sclerosis (scleroderma).

Authors:  L D Kaufman; B L Gruber; M J Marchese; J R Seibold
Journal:  Ann Rheum Dis       Date:  1989-03       Impact factor: 19.103

10.  FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice.

Authors:  S Paveglio; L Puddington; E Rafti; A P Matson
Journal:  Clin Exp Allergy       Date:  2012-12       Impact factor: 5.018
  10 in total

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