Anti-rheumatic and analgesic drug usage and acute gastro-intestinal bleeding in elderly patients.

The records of 1878 general medical in-patients (aged 75 years and over) at Hereford have been examined for associations between the commonly used antirheumatic and analgesic drugs and acute gastro-intestinal bleeding. One third of 93 in-patients admitted because of acute bleeding had been taking ibuprofen, indomethacin or aspirin. The usage of these drugs was significantly greater than in the control population who comprised the remaining 1785 elderly medical in-patients. It is suggested that very elderly patients taking any of these three drugs form a vulnerable high risk group who are liable to develop acute gastro-intestinal bleeding.