Literature DB >> 3872922

Interleukin 2-induced proliferation of leukemic human B cells.

O Lantz, C Grillot-Courvalin, C Schmitt, J P Fermand, J C Brouet.   

Abstract

The proliferative responses of purified leukemic human B cells from nine B cell chronic lymphocytic leukemias to recombinant interleukin 2 (IL-2), spontaneously, and after preactivation by Staphylococcus aureus Cowan I (SAC) or anti-mu antibodies were studied. Three patterns of response were observed: (a) no response (three cases); (b) a moderate spontaneous response enhanced by anti-mu (one case); (c) a high proliferative response after preactivation by anti-mu and/or SAC (five cases). IL-2 could also trigger normal B cells, purified from spleen, to proliferative after preactivation by anti-mu or SAC. These results provide evidence that IL-2 is a lymphokine that acts physiologically on both B and T cells.

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Year:  1985        PMID： 3872922      PMCID： PMC2187614          DOI： 10.1084/jem.161.5.1225

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

1.  T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors:  S Gillis; M M Ferm; W Ou; K A Smith
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

2.  Proliferative responses of normal human B lymphocytes. Development of an assay system for human B cell growth factor (BCGF).

Authors:  A Muraguchi; A S Fauci
Journal:  J Immunol       Date:  1982-09       Impact factor: 5.422

3.  First French workshop on standardization of human IL-2: joint report.

Authors: 
Journal:  Lymphokine Res       Date:  1982

4.  Surface bound immunoglobulins as a cell marker in human lymphoproliferative diseases.

Authors:  J L Preud'homme; M Seligmann
Journal:  Blood       Date:  1972-12       Impact factor: 22.113

5.  Mitogen-induced maturation of chronic lymphocytic leukemia B lymphocytes.

Authors:  P Guglielmi; J L Preud'homme; R Ciorbaru-Barot; M Seligmann
Journal:  J Clin Immunol       Date:  1982-07       Impact factor: 8.317

6.  B cell growth factor and T cell growth factor produced by mitogen-stimulated normal human peripheral blood T lymphocytes are distinct molecules.

Authors:  A Muraguchi; T Kasahara; J J Oppenheim; A S Fauci
Journal:  J Immunol       Date:  1982-12       Impact factor: 5.422

7.  Human B cell activation and cell cycle progression: stimulation with anti-mu and Staphylococcus aureus Cowan strain I.

Authors:  J H Kehrl; A Muraguchi; A S Fauci
Journal:  Eur J Immunol       Date:  1984-02       Impact factor: 5.532

8.  Differential sensitivity of human B cell subsets to activation signals delivered by anti-mu antibody and proliferative signals delivered by a monoclonal B cell growth factor.

Authors:  A Muraguchi; J L Butler; J H Kehrl; A S Fauci
Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307

9.  Helper signals in the plaque-forming cell response to protein-bound haptens.

Authors:  N W Roehm; P Marrack; J W Kappler
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

10.  Expression of Tac antigen on activated normal human B cells.

Authors:  M Tsudo; T Uchiyama; H Uchino
Journal:  J Exp Med       Date:  1984-08-01       Impact factor: 14.307
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  17 in total

Review 1.  Growth and survival of B-chronic lymphocytic leukaemia cells.

Authors:  O Söderberg
Journal:  Med Oncol       Date:  1998-07       Impact factor: 3.064

2.  Expression of Tac antigen in B cell lymphomas.

Authors:  G Laurent; T Al Saati; D Olive; J C Laurent; P Poncelet; G Delsol
Journal:  Clin Exp Immunol       Date:  1986-08       Impact factor: 4.330

Review 3.  Mechanisms of physiologic B cell responses and B cell hyperactivity in systemic lupus erythematosus.

Authors:  R H Zubler; Y P Huang; P A Miescher
Journal:  Springer Semin Immunopathol       Date:  1986

4.  Direct effect of interleukin 2 on chronic lymphocytic leukaemia B cell functions and morphology.

Authors:  V Malkovska; J Murphy; L Hudson; D Bevan
Journal:  Clin Exp Immunol       Date:  1987-06       Impact factor: 4.330

5.  Expression of p55 (Tac) interleukin-2 receptor (IL-2R), but not p75 IL-2R, in cultured H-RS cells and H-RS cells in tissues.

Authors:  S M Hsu; C K Tseng; P L Hsu
Journal:  Am J Pathol       Date:  1990-04       Impact factor: 4.307

6.  Demonstration of high-affinity interleukin-2 receptors on B-chronic lymphocytic leukemia cells: functional and structural characterization.

Authors:  H Yagura; T Tamaki; T Furitsu; Y Tomiyama; T Nishiura; N Tominaga; S Katagiri; T Yonezawa; S Tarui
Journal:  Blut       Date:  1990-03

7.  Sex hormones and immune dysregulation in multiple myeloma.

Authors:  H Everaus; J Lehtmaa
Journal:  Cancer Immunol Immunother       Date:  1993       Impact factor: 6.968

8.  Immune and hormonal changes in early-stage chronic lymphocytic leukemia patients.

Authors:  H Everaus; J Lehtmaa; E Luik; H Kŏdar
Journal:  Ann Hematol       Date:  1992-11       Impact factor: 3.673

9.  C-kinase activity in normal B cells treated with Staphylococcus aureus, Cowan strain I, and phorbol ester: response differences in a patient with prolymphocytic leukaemia.

Authors:  R Cooper; J Louw; J Daniels; D P de Beer; A E Nel
Journal:  Immunology       Date:  1987-08       Impact factor: 7.397

10.  Activation of B chronic lymphocytic leukaemia cells by Branhamella catarrhalis.

Authors:  J E Calvert; S J Proctor; R Jefferis
Journal:  Immunology       Date:  1987-01       Impact factor: 7.397
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