Peripheral vascular H2 receptors to histamine.

The development of two different types of antagonists to the many actions of histamine has permitted exploration of vascular receptors to the amine. Certain cautions are necessary to avoid inaccurate conclusions in such studies, however. From available literature it appears that both H1 and H2 receptors to histamine are widely distributed in the circulation. In a given regional vasculature discrete actions of each receptor may be evident.