Literature DB >> 3872621

In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomography.

D A Rottenberg, J Z Ginos, K J Kearfott, L Junck, V Dhawan, J O Jarden.   

Abstract

In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using [11C]dimethyloxazolidinedione [( 11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our results, which are consistent with reported [14C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more "acidic" than that of normal gray or white matter.

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Year:  1985        PMID： 3872621     DOI： 10.1002/ana.410170116

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  17 in total

1.  Quantification of in vivo ³¹P NMR brain spectra using LCModel.

Authors:  Dinesh Kumar Deelchand; Tra-My Nguyen; Xiao-Hong Zhu; Fanny Mochel; Pierre-Gilles Henry
Journal:  NMR Biomed       Date:  2015-04-14       Impact factor: 4.044

Review 2.  Radiopharmaceuticals as probes to characterize tumour tissue.

Authors:  Israt S Alam; Mubarik A Arshad; Quang-Dé Nguyen; Eric O Aboagye
Journal:  Eur J Nucl Med Mol Imaging       Date:  2015-02-03       Impact factor: 9.236

3.  Cyclase-associated protein (CAP) acts directly on F-actin to accelerate cofilin-mediated actin severing across the range of physiological pH.

Authors:  Kieran P M Normoyle; William M Brieher
Journal:  J Biol Chem       Date:  2012-08-17       Impact factor: 5.157

4.  Expression of hypoxia-inducible carbonic anhydrases in brain tumors.

Authors:  Martin A Proescholdt; Christina Mayer; Marion Kubitza; Thomas Schubert; Shu-Yuan Liao; Eric J Stanbridge; Sergey Ivanov; Edward H Oldfield; Alexander Brawanski; Marsha J Merrill
Journal:  Neuro Oncol       Date:  2005-10       Impact factor: 12.300

5.  Development of luminescent pH sensor films for monitoring bacterial growth through tissue.

Authors:  Fenglin Wang; Yash Raval; Hongyu Chen; Tzuen-Rong J Tzeng; John D DesJardins; Jeffrey N Anker
Journal:  Adv Healthc Mater       Date:  2013-07-05       Impact factor: 9.933

Review 6.  Brain tumors.

Authors:  K L Black; J C Mazziotta; D P Becker
Journal:  West J Med       Date:  1991-02

7.  In vivo measurement of regional brain and tumor pH using [14C]dimethyloxazolidinedione and quantitative autoradiography. II: Characterization of the extracellular fluid compartment using pH-sensitive microelectrodes and [14C]sucrose.

Authors:  J B Arnold; R P Kraig; D A Rottenberg
Journal:  J Cereb Blood Flow Metab       Date:  1986-08       Impact factor: 6.200

8.  Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.

Authors:  D E Korenchan; R R Flavell; C Baligand; R Sriram; K Neumann; S Sukumar; H VanBrocklin; D B Vigneron; D M Wilson; J Kurhanewicz
Journal:  Chem Commun (Camb)       Date:  2016-02-18       Impact factor: 6.222

9.  Simultaneous double-isotope autoradiographic measurement of local cerebral glucose metabolic rate and acid-base status in rat brain.

Authors:  A H Lockwood; K E Peek; M Berridge; L Bogue; E Yap
Journal:  Metab Brain Dis       Date:  1987-03       Impact factor: 3.584

10.  Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.

Authors:  Robert R Flavell; Charles Truillet; Melanie K Regan; Tanushree Ganguly; Joseph E Blecha; John Kurhanewicz; Henry F VanBrocklin; Kayvan R Keshari; Christopher J Chang; Michael J Evans; David M Wilson
Journal:  Bioconjug Chem       Date:  2015-12-22       Impact factor: 4.774
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