Literature DB >> 3872479

Coagulopathy and hemorrhage associated with cefoperazone therapy in a patient with renal failure.

T D Shenkenberg, P A Mackowiak, J W Smith.   

Abstract

We have reported life-threatening gastrointestinal hemorrhage with hypoprothrombinemia in a patient treated with cefoperazone for a urinary tract infection. The coagulation abnormality was rapidly corrected with administration of vitamin K and discontinuation of the antibiotic. This complication of cefoperazone therapy is not widely recognized and may be seen more frequently with increased use of the drug.

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Year:  1985        PMID: 3872479     DOI: 10.1097/00007611-198504000-00035

Source DB:  PubMed          Journal:  South Med J        ISSN: 0038-4348            Impact factor:   0.954


  3 in total

1.  Cefoperazone/Sulbactam-Induced Abdominal Wall Hematoma and Upper Gastrointestinal Bleeding: A Case Report and Review of the Literature.

Authors:  ZhuYing Cai; Wei Yang; YingYing He; Qingge Chen; ShiQiang Wang; Xuming Luo; Xiongbiao Wang
Journal:  Drug Saf Case Rep       Date:  2016-12

2.  Fatal Vitamin K-Dependent Coagulopathy Associated with Cefoperazone/Sulbactam: A Case Report.

Authors:  Huan-Rong Hu
Journal:  Drug Saf Case Rep       Date:  2019-06-14

3.  Neglected vitamin K deficiency causing coagulation dysfunction in an older patient with pneumonia: a case report.

Authors:  Qiaoping Wu; Lufeng Wang; Rongqing Zhao
Journal:  BMC Geriatr       Date:  2022-07-30       Impact factor: 4.070

  3 in total

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