Literature DB >> 387208

Clinical toxicologic and pharmacologic studies of gallium nitrate.

I H Krakoff, R A Newman, R S Goldberg.   

Abstract

Gallium nitrate, administered intravenously to patients with advanced cancer, produced renal functional abnormalities consistently at a dose of 750 mg/m2. The toxicity at that dose could be modified by fluid loading and osmotic diuresis. Pharmacokinetic studies revealed a biphasic half-life, (T 1/2 alpha = 87 minutes and T 1/2 beta = 24.5 hours). Osmotic diuresis reduced the urinary concentration of gallium but did not affect serum levels or clearance.

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Year:  1979        PMID： 387208     DOI： 10.1002/1097-0142(197911)44:5<1722::aid-cncr2820440528>3.0.co;2-c

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  22 in total

1.  Gallium disrupts iron metabolism of mycobacteria residing within human macrophages.

Authors:  O Olakanmi; B E Britigan; L S Schlesinger
Journal:  Infect Immun       Date:  2000-10       Impact factor: 3.441

2.  Gallium Compounds Exhibit Potential as New Therapeutic Agents against Mycobacterium abscessus.

Authors:  Maher Y Abdalla; Barbara L Switzer; Christopher H Goss; Moira L Aitken; Pradeep K Singh; Bradley E Britigan
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

Review 3.  Gallium-containing anticancer compounds.

Authors:  Christopher R Chitambar
Journal:  Future Med Chem       Date:  2012-06       Impact factor: 3.808

4.  Phase II trial of gallium nitrate, amonafide and teniposide in metastatic non-small cell lung cancer. An Eastern Cooperative Oncology Group study (E2588).

Authors:  A Y Chang; Z N Tu; J L Smith; P Bonomi; T J Smith; P H Wiernik; R Blum
Journal:  Invest New Drugs       Date:  1995       Impact factor: 3.850

Review 5.  Gallium nitrate. A review of its pharmacological properties and therapeutic potential in cancer related hypercalcaemia.

Authors:  P A Todd; A Fitton
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

Review 6.  Medical applications and toxicities of gallium compounds.

Authors:  Christopher R Chitambar
Journal:  Int J Environ Res Public Health       Date:  2010-05-10       Impact factor: 3.390

Review 7.  Drugs used in the treatment of metabolic bone disease. Clinical pharmacology and therapeutic use.

Authors:  S Patel; A R Lyons; D J Hosking
Journal:  Drugs       Date:  1993-10       Impact factor: 9.546

8.  Gallium nitrate inhibits calcium resorption from bone and is effective treatment for cancer-related hypercalcemia.

Authors:  R P Warrell; R S Bockman; C J Coonley; M Isaacs; H Staszewski
Journal:  J Clin Invest       Date:  1984-05       Impact factor: 14.808

Review 9.  Complexes of metals other than platinum as antitumour agents.

Authors:  P Köpf-Maier
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

10.  Developmental toxicity evaluation of gallium nitrate in mice.

Authors:  M Gómez; D J Sánchez; J L Domingo; J Corbella
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153
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