Literature DB >> 387147

Inhibition of insulin secretion from the perfused pancreas of the rat by pizotifen.

H G Joost.   

Abstract

1 In the perfused rat pancreas the effects of pizotifen on insulin release induced by 20 mM glucose were studied. 2 Pizotifen (10 and 100 muM) significantly reduced the insulin release during a 25 min perfusion period to 49% and 7% of the controls. 3 The same concentrations of the structurally related agents cyproheptadine, doxepin, and chlorpromazine produced a comparable inhibition.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 387147      PMCID： PMC2043895          DOI： 10.1111/j.1476-5381.1979.tb08675.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  22 in total

1.  EFFECTS OF CARBOHYDRATES ON SECRETION OF INSULIN FROM ISOLATED RAT PANCREAS.

Authors:  G M GRODSKY; A A BATTS; L L BENNETT; C VCELLA; N B MCWILLIAMS; D F SMITH
Journal:  Am J Physiol       Date:  1963-10

2.  An antaminic drug, BC 105, in the prophylaxis of migraine. Pharmacological, clinical, and therapeutic experiences.

Authors:  F Sicuteri; G Franchi; P L Del Bianco
Journal:  Int Arch Allergy Appl Immunol       Date:  1967

3.  [Effects of a serotonin antagonist (BC 105 Sandoz) on carbohydrate metabolism].

Authors:  C Fraipont-Guyot; A Luyckx; P Lefebvre
Journal:  Rev Med Liege       Date:  1970-07

4.  Pharmacological properties of 4(1-methyl-4-piperidylidine)-9,10-dihydro-4H-benzo-[4,5]cyclohepta[1,2]-thiophene hydrogen maleate (pizotifen).

Authors:  A K Dixon; R C Hill; D Roemer; G Scholtysik
Journal:  Arzneimittelforschung       Date:  1977

5.  Inhibition of insulin release from the rat pancreas by cyproheptadine and tricyclic antidepressants.

Authors:  H G Joost; W Poser; U Panten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

6.  The action of BC-105 in chronic schizophrenics with depression.

Authors:  W V Krumholz; J A Yaryura-Tobias; L White
Journal:  Curr Ther Res Clin Exp       Date:  1968-07

7.  Effect of chlorpromazine on blood glucose and plasma insulin in man.

Authors:  G Erle; M Basso; G Federspil; N Sicolo; C Scandellari
Journal:  Eur J Clin Pharmacol       Date:  1977       Impact factor: 2.953

Review 8.  Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches.

Authors:  T M Speight; G S Avery
Journal:  Drugs       Date:  1972       Impact factor: 9.546

9.  Accumulation of dopamine in mouse pancreatic B-cells following injection of L-DOPA. Localization to secretory granules and inhibition of insulin secretion.

Authors:  L E Ericson; R Håkanson; I Lundquist
Journal:  Diabetologia       Date:  1977-04       Impact factor: 10.122

10.  Subcellular B cell calcium and insulin secretion in vitro. Comparative ultracytochemical studies after glucose stimulation and cyproheptadine inhibition.

Authors:  G Bommer; H G Joost; G Klöppel
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1978-09-07
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.