Literature DB >> 3865371

Identification of a transcriptional enhancer element upstream from the proto-oncogene fos.

J Deschamps, F Meijlink, I M Verma.   

Abstract

Sequences upstream from the proto-oncogene fos were shown to be essential for its transcription. Transient expression of the chloramphenicol acetyl-transferase (CAT) gene linked to upstream sequences of the fos gene including its promoter reveals that sequences located 64 to 404 base pairs 5' to the fos cap site contain a typical transcriptional enhancer. Moreover, these enhancer sequences, which are strikingly conserved between mouse and human fos genes, coincide with a deoxyribonuclease I-hypersensitive site in the chromatin. The expression of the fos-CAT fusion genes was stimulated only two to three times by the fos inducer 12-0-tetradecanoyl phorbol-13-acetate. The fos enhancer does not appear to be tissue-specific.

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Year:  1985        PMID： 3865371     DOI： 10.1126/science.3865371

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  54 in total

1.  Overlap of the p53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type I.

Authors:  N Aoyama; T Nagase; T Sawazaki; G Mizuguchi; H Nakagoshi; J I Fujisawa; M Yoshida; S Ishii
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

2.  Transcriptional regulation of early-response genes during polyomavirus infection.

Authors:  G M Glenn; W Eckhart
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

3.  Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling.

Authors:  K Schilling; D Luk; J I Morgan; T Curran
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

4.  The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.

Authors:  C Venot; M Maratrat; C Dureuil; E Conseiller; L Bracco; L Debussche
Journal:  EMBO J       Date:  1998-08-17       Impact factor: 11.598

5.  Serum stimulation of the c-fos enhancer induces reversible changes in c-fos chromatin structure.

Authors:  J L Feng; B Villeponteau
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

6.  c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

Authors:  M Fujii; P Sassone-Corsi; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

7.  Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes.

Authors:  J Visvader; P Sassone-Corsi; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

8.  Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.

Authors:  G M Glenn; W Eckhart
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

9.  CREB represses transcription of fos promoter: role of phosphorylation.

Authors:  R Ofir; V J Dwarki; D Rashid; I M Verma
Journal:  Gene Expr       Date:  1991-04

10.  c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain.

Authors:  M Hatakeyama; A Kawahara; H Mori; H Shibuya; T Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205
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