Literature DB >> 3864755

The relationship between 17 beta hydroxysteroid dehydrogenase and breast tumour site and size.

P A Beranek, E J Folkerd, C J Newton, M J Reed, M W Ghilchik, V H James.   

Abstract

The activity of 17 beta hydroxysteroid dehydrogenase (170HSD) was measured in adipose tissue adjacent to benign or malignant breast tumours. 170HSD activity was significantly correlated with tumour size in malignant tumours (r = 0.75) but not with benign tumours (r = 0.28). Enzyme activity was reduced in adipose tissue adjacent to tumours obtained from inferior breast quadrants.

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Year:  1985        PMID: 3864755     DOI: 10.1002/ijc.2910360611

Source DB:  PubMed          Journal:  Int J Cancer        ISSN: 0020-7136            Impact factor:   7.396


  3 in total

1.  Inhibitory effects of medroxyprogesterone acetate (MPA) and the pure antiestrogen EM-219 on estrone (E1)-stimulated growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat.

Authors:  S Li; C Lévesque; C S Geng; X Yan; F Labrie
Journal:  Breast Cancer Res Treat       Date:  1995-05       Impact factor: 4.872

2.  Site-directed mutagenesis of the putative active site of human 17 beta-hydroxysteroid dehydrogenase type 1.

Authors:  T J Puranen; M H Poutanen; H E Peltoketo; P T Vihko; R K Vihko
Journal:  Biochem J       Date:  1994-11-15       Impact factor: 3.857

3.  Breast tumor-derived factors stimulate reduction of estrone to estradiol in nonmalignant breast tissue.

Authors:  R R Mehta; J M Graves
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

  3 in total

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