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Literature DB >> 386281

Molecular cloning and nucleotide sequence of the human growth hormone structural gene.

Abstract

An almost complete cDNA copy of human growth hormone has been cloned and sequenced. The nucleotide sequence confirms the known protein sequence and predicts the sequence of a precursor region of 26 amino acids. We have compared the nucleotide sequence to that for the homolgous proteins, rat growth hormone and human chorionic somatomammotropin (Seeburg et al. and Shine et al., Nature 270, 486 (1977)). There appears to be evolutionary conservation of mRNA sequence features not related to protein structure.

Entities: Gene Species

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Year: 1979 PMID： 386281 PMCID： PMC328019 DOI： 10.1093/nar/7.2.305

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

53 in total

1. Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns.

Authors: J van den Berg; A van Ooyen; N Mantei; A Schamböck; G Grosveld; R A Flavell; C Weissmann
Journal: Nature Date: 1978-11-02 Impact factor: 49.962

2. Molecular evolution of human and rabbit beta-globin mRNAs.

Authors: F C Kafatos; A Efstratiadis; B G Forget; S M Weissman
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

3. Construction and identification by positive hybridization-translation of a bacterial plasmid containing a rat growth hormone structural gene sequence.

Authors: M M Harpold; P R Dobner; R M Evans; F C Bancroft
Journal: Nucleic Acids Res Date: 1978-06 Impact factor: 16.971

4. Organisation and sequences at the 5' end of a cloned complete ovalbumin gene.

Authors: F Gannon; K O'Hare; F Perrin; J P LePennec; C Benoist; M Cochet; R Breathnach; A Royal; A Garapin; B Cami; P Chambon
Journal: Nature Date: 1979-03-29 Impact factor: 49.962

5. Sequence of the 5'-end of Strongylocentrotus purpuratus H2b histone mRNA and its location within histone DNA.

Authors: S Levy; I Sures; L H Kedes
Journal: Nature Date: 1979-06-21 Impact factor: 49.962

6. Evolution of the differential regulation of duplicate genes after polyploidization.

Authors: S D Ferris; G S Whitt
Journal: J Mol Evol Date: 1979-04-12 Impact factor: 2.395

7. Complete 3' noncoding region sequences of rabbit and human beta-globin messenger RNAs.

Authors: N J Proudfoot
Journal: Cell Date: 1977-04 Impact factor: 41.582

8. Relationship between size, stability and abundance of the messenger RNA of mouse L cells.

Authors: O Meyuhas; R P Perry
Journal: Cell Date: 1979-01 Impact factor: 41.582

9. AUG is the only recognisable signal sequence in the 5' non-coding regions of eukaryotic mRNA.

Authors: F E Baralle; G G Brownlee
Journal: Nature Date: 1978-07-06 Impact factor: 49.962

10. Cloning and amplification of rabbit alpha- and beta-globin gene sequences into Escherichia coli plasmids.

Authors: F Rougeon; B Mach
Journal: J Biol Chem Date: 1977-04-10 Impact factor: 5.157

22 in total

1. Purification of the mRNA for chicken very low density lipoproteinII and molecular cloning of its full-length double-stranded cDNA.

Authors: B Wieringa; W Roskam; A Arnberg; J van der Zwaag-Gerritsen; G Ab; M Gruber
Journal: Nucleic Acids Res Date: 1979-12-20 Impact factor: 16.971

Molecular cloning and nucleotide sequence of the human growth hormone structural gene.

1. Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns.

2. Molecular evolution of human and rabbit beta-globin mRNAs.

3. Construction and identification by positive hybridization-translation of a bacterial plasmid containing a rat growth hormone structural gene sequence.

4. Organisation and sequences at the 5' end of a cloned complete ovalbumin gene.

5. Sequence of the 5'-end of Strongylocentrotus purpuratus H2b histone mRNA and its location within histone DNA.

6. Evolution of the differential regulation of duplicate genes after polyploidization.

7. Complete 3' noncoding region sequences of rabbit and human beta-globin messenger RNAs.

8. Relationship between size, stability and abundance of the messenger RNA of mouse L cells.

9. AUG is the only recognisable signal sequence in the 5' non-coding regions of eukaryotic mRNA.

10. Cloning and amplification of rabbit alpha- and beta-globin gene sequences into Escherichia coli plasmids.

1. Purification of the mRNA for chicken very low density lipoproteinII and molecular cloning of its full-length double-stranded cDNA.

2. Glucocorticoids enhance stability of human growth hormone mRNA.

3. Nucleic acid composition, codon usage, and the rate of synonymous substitution in protein-coding genes.

4. The statistical distribution of nucleic acid similarities.

5. Codon frequencies in 119 individual genes confirm consistent choices of degenerate bases according to genome type.

6. Inter-RNA homology and possible roles of small RNAs.

7. The orderly splicing of the first three leaders of the adenovirus-2 major late transcript.

8. Genetic and molecular analysis of familial isolated growth hormone deficiency.

9. Mouse immunoglobulin genes: a bacterial plasmid containing the entire coding sequence for a pre-gamma 2a heavy chain.

10. Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats.