Literature DB >> 386109

Mutagenicity evaluation of the two antimalarial agents chloroquine and mefloquine, using a bacterial fluctuation test.

M E Schüpbach.   

Abstract

The two antimalarial agents chloroquine and mefloquine have been tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537 and TA1538. Chloroquine was found to revert strain TA1537 at concentrations of 100 and 250 micrograms/ml, most likely due to intercalation. No mutagenicity was found with mefloquine at concentrations up to 2.5 micrograms/ml, neither without nor with metabolic activation by Ca2+-precipitated rat liver microsomes. Higher concentrations of mefloquine and chloroquine inactivated the bacteria.

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Year:  1979        PMID： 386109     DOI： 10.1016/0165-1218(79)90076-4

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  3 in total

1.  Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.

Authors:  Sunetra Ray; Peter B Madrid; Paul Catz; Susanna E LeValley; Michael J Furniss; Linda L Rausch; R Kiplin Guy; Joseph L DeRisi; Lalitha V Iyer; Carol E Green; Jon C Mirsalis
Journal:  J Med Chem       Date:  2010-05-13       Impact factor: 7.446

2.  Quinine induced Escherichia coli DNA base-pair substitution mutation.

Authors:  E E Obaseiki-Ebor; E E Obasi
Journal:  Bull Environ Contam Toxicol       Date:  1987-03       Impact factor: 2.151

3.  Comparison of the Ames assay and the induction of sister chromatid exchanges: results with ten pharmaceuticals and five selected agents.

Authors:  E K Shubber; D Jacobson-Kram; J R Williams
Journal:  Cell Biol Toxicol       Date:  1986-09       Impact factor: 6.691
  3 in total

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