Literature DB >> 3859410

The preparation and characterisation of 111In-labelled 791T/36 monoclonal antibody for tumour immunoscintigraphy.

A C Perkins, M V Pimm, M K Birch.   

Abstract

The anti-human tumour monoclonal antibody 791T/36 was conjugated to the cyclic dianhydride of DTPA and radio-labelled with 111In. The labelling method proved to be both simple and reliable and would be suitable for routine clinical use. Subsequent characterisation of this radio-pharmaceutical in vitro and in tumour-bearing hosts gave a strong indication as to its suitability for clinical tumour localisation studies.

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Year:  1985        PMID： 3859410     DOI： 10.1007/bf00251299

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  19 in total

1.  In vivo localization of anti-osteogenic sarcoma 791T monoclonal antibody in osteogenic sarcoma xenografts.

Authors:  M V Pimm; M J Embleton; A C Perkins; M R Price; R A Robins; G R Robinson; R W Baldwin
Journal:  Int J Cancer       Date:  1982-07-15       Impact factor: 7.396

2.  Radioimmunodetection of human colorectal cancers by an anti-tumour monoclonal antibody.

Authors:  P A Farrands; A C Perkins; M V Pimm; M J Embleton; J D Hardy; R W Baldwin; J D Hardcastle
Journal:  Lancet       Date:  1982-08-21       Impact factor: 79.321

3.  Targeting of iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours.

Authors:  A A Epenetos; K E Britton; S Mather; J Shepherd; M Granowska; J Taylor-Papadimitriou; C C Nimmon; H Durbin; L R Hawkins; J S Malpas; W F Bodmer
Journal:  Lancet       Date:  1982-11-06       Impact factor: 79.321

4.  The localization of an anti-tumour monoclonal antibody (791T/36) in gastrointestinal tumours.

Authors:  N C Armitage; A C Perkins; M V Pimm; P A Farrands; R W Baldwin; J D Hardcastle
Journal:  Br J Surg       Date:  1984-06       Impact factor: 6.939

5.  Clinical implications for immunoscintigraphy in patients with ovarian malignancy: a preliminary study using monoclonal antibody 791T/36.

Authors:  E M Symonds; A C Perkins; M V Pimm; R W Baldwin; J G Hardy; D A Williams
Journal:  Br J Obstet Gynaecol       Date:  1985-03

6.  The preparation and labeling of DTPA-coupled albumin.

Authors:  D J Hnatowich; W W Layne; R L Childs
Journal:  Int J Appl Radiat Isot       Date:  1982-05

7.  Location of metastatic breast carcinoma by a monoclonal antibody chelate labelled with indium-111.

Authors:  R M Rainsbury; R J Ott; J H Westwood; T S Kalirai; R C Coombes; V R McCready; A M Neville; J C Gazet
Journal:  Lancet       Date:  1983-10-22       Impact factor: 79.321

8.  Improved tumour localisation using indium-111 labelled antibodies.

Authors:  D S Fairweather; A R Bradwell; P W Dykes; A T Vaughan; S F Watson-James; S Chandler
Journal:  Br Med J (Clin Res Ed)       Date:  1983-07-16

9.  The use of monoclonal antibody 791T/36 in the immunoscintigraphy of primary and metastatic carcinoma of the breast.

Authors:  M R Williams; A C Perkins; F C Campbell; M V Pimm; J G Hardy; M L Wastie; R W Blamey; R W Baldwin
Journal:  Clin Oncol       Date:  1984-12

10.  Localization of human tumour xenografts after i.v. administration of radiolabeled monoclonal antibodies.

Authors:  V Moshakis; R A McIlhinney; D Raghavan; A M Neville
Journal:  Br J Cancer       Date:  1981-07       Impact factor: 7.640
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  12 in total

1.  The localization of anti-tumour monoclonal antibodies in colorectal cancer.

Authors:  N C Armitage
Journal:  Ann R Coll Surg Engl       Date:  1986-11       Impact factor: 1.891

2.  Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. II. Biodistribution studies in mice with human tumour xenografts.

Authors:  M V Pimm; A C Perkins; R W Baldwin
Journal:  Eur J Nucl Med       Date:  1985

3.  Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. I. The effect on image contrast in clinical studies.

Authors:  A C Perkins; M V Pimm
Journal:  Eur J Nucl Med       Date:  1985

4.  Gamma camera emission tomography using radiolabelled antibodies.

Authors:  A C Perkins; D R Whalley; K C Ballantyne; M V Pimm
Journal:  Eur J Nucl Med       Date:  1988

5.  Labeling of monoclonal antibodies with a 67Ga-phenolic aminocarboxylic acid chelate. Part II. Comparison of immunoreactivity and biodistribution of monoclonal antibodies labeled with the 67Ga-chelate or with 131I.

Authors:  S Matzku; J Schuhmacher; H Kirchgessner; J Brüggen
Journal:  Eur J Nucl Med       Date:  1986

6.  Labeling of monoclonal antibodies with a 67Ga-phenolic aminocarboxylic acid chelate. Part I. Chemistry and labeling technique.

Authors:  J Schuhmacher; R Matys; H Hauser; W Maier-Borst; S Matzku
Journal:  Eur J Nucl Med       Date:  1986

7.  Inhibition of the hepatocyte uptake of radiolabelled monoclonal antibodies by chelating agents.

Authors:  B R Davidson; P B Boulos; J B Porter
Journal:  Eur J Nucl Med       Date:  1990

8.  Diverse characteristics of 111In labelled anti-CEA monoclonal antibodies for tumour immunoscintigraphy: radiolabelling, biodistribution and imaging studies in mice with human tumour xenografts.

Authors:  M V Pimm; A C Perkins; R W Baldwin
Journal:  Eur J Nucl Med       Date:  1987

9.  Comparative tumour localization properties of radiolabelled monoclonal antibody preparations of defined immunoreactivities.

Authors:  M V Pimm; R W Baldwin
Journal:  Eur J Nucl Med       Date:  1987

10.  Biodistribution in tumour-bearing mice of polycationic, amphoteric and polyanionic branched polypeptides with a poly(L-lysine) backbone labelled with 125I and 111In: tumour accumulation less than that of labelled serum proteins.

Authors:  M V Pimm; F Hudecz
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553
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