Literature DB >> 3859295

Isolation from Cannabis sativa L. of cannflavin--a novel inhibitor of prostaglandin production.

M L Barrett, D Gordon, F J Evans.   

Abstract

The isolation from Cannabis sativa L. of an inhibitor of prostaglandin (PG) E2 production by cultured rheumatoid synovial cells is described. This agent, for which the name Cannflavin has been coined, is distinct from cannabinoids on the basis of isolation procedure, preliminary structural analysis and biological properties. The activity of Cannflavin has been compared with several established anti-inflammatory drugs and the major cannabinoids.

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Year:  1985        PMID： 3859295     DOI： 10.1016/0006-2952(85)90325-9

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  7 in total

1.  Analgesic and antiinflammatory activity of constituents of Cannabis sativa L.

Authors:  E A Formukong; A T Evans; F J Evans
Journal:  Inflammation       Date:  1988-08       Impact factor: 4.092

Review 2.  Cannabinoids, endocannabinoids, and related analogs in inflammation.

Authors:  Sumner H Burstein; Robert B Zurier
Journal:  AAPS J       Date:  2009-02-06       Impact factor: 4.009

3.  Flavonoid Derivative of Cannabis Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer.

Authors:  Michele Moreau; Udoka Ibeh; Kaylie Decosmo; Noella Bih; Sayeda Yasmin-Karim; Ngeh Toyang; Henry Lowe; Wilfred Ngwa
Journal:  Front Oncol       Date:  2019-07-23       Impact factor: 6.244

4.  Analysis of Phenolic Compounds in Commercial Cannabis sativa L. Inflorescences Using UHPLC-Q-Orbitrap HRMS.

Authors:  Luana Izzo; Luigi Castaldo; Alfonso Narváez; Giulia Graziani; Anna Gaspari; Yelko Rodríguez-Carrasco; Alberto Ritieni
Journal:  Molecules       Date:  2020-01-31       Impact factor: 4.411

5.  The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar.

Authors:  Janina K Bowen; Jacqueline M Chaparro; Alexander M McCorkle; Edward Palumbo; Jessica E Prenni
Journal:  Sci Rep       Date:  2021-11-08       Impact factor: 4.379

6.  Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer.

Authors:  Andrea M Tomko; Erin G Whynot; Denis J Dupré
Journal:  J Cannabis Res       Date:  2022-07-22

7.  Genome-wide identification of key enzyme-encoding genes and the catalytic roles of two 2-oxoglutarate-dependent dioxygenase involved in flavonoid biosynthesis in Cannabis sativa L.

Authors:  Xuewen Zhu; Yaolei Mi; Xiangxiao Meng; Yiming Zhang; Weiqiang Chen; Xue Cao; Huihua Wan; Wei Yang; Jun Li; Sifan Wang; Zhichao Xu; Atia Tul Wahab; Shilin Chen; Wei Sun
Journal:  Microb Cell Fact       Date:  2022-10-15       Impact factor: 6.352
  7 in total

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