Literature DB >> 3857607

Detection in extracts of bovine brain of lipophilic complexes of sulfate esters of cholesterol and beta-sitosterol.

V V Prasad, E el-Maraghy, L Ponticorvo, S Lieberman.   

Abstract

Evidence indicating that there exist in bovine brains hitherto-unrecognized lipophilic conjugates of sterol sulfates is presented. These conjugates are soluble in nonpolar solvents and, when heated in methanol containing pyridine, yield polar sterol conjugates. These polar substances have the chromatographic mobility of sterol sulfates and are cleaved to free sterols when subjected to a solvolytic process known to be specific for sulfate esters. The brain sterols that have been identified in this way are cholesterol and beta-sitosterol.

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Year:  1985        PMID： 3857607      PMCID： PMC397623          DOI： 10.1073/pnas.82.9.2657

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  8 in total

1.  ISOLATION OF CHOLESTEROL SULFATE FROM HUMAN BLOOD AND GALLSTONES.

Authors:  N M DRAYER; S LIEBERMAN
Journal:  Biochem Biophys Res Commun       Date:  1965-01-04       Impact factor: 3.575

2.  EVIDENCE THAT STEROID SULFATES SERVE AS BIOSYNTHETIC INTERMEDIATES. IV. CONVERSION OF CHOLESTEROL SULFATE IN VIVO TO URINARY C-19 AND C-21 STEROIDAL SULFATES.

Authors:  K D ROBERTS; L BANDI; H I CALVIN; W D DRUCKER; S LIEBERMAN
Journal:  Biochemistry       Date:  1964-12       Impact factor: 3.162

3.  [On steroid conjugates in plasma. I. Isolation of sulfate-, phosphate- and lipoid-containing 17-ketosteroid conjugates in human blood plasma].

Authors:  G W OERTEL
Journal:  Biochem Z       Date:  1961

4.  Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures.

Authors:  S BURSTEIN; S LIEBERMAN
Journal:  J Biol Chem       Date:  1958-08       Impact factor: 5.157

5.  [On steroid conjugates in the plasma. IV. Chromatography of steroid conjugates on ion exchangers and use in the isolation of 17-ketosteroid conjugates from the peripheral plasma].

Authors:  W OERTEL; E KAISER
Journal:  Biochem Z       Date:  1962

6.  Preliminary observations on the occurrence of cholesterol sulfate in man.

Authors:  H W Moser; A B Moser; J C Orr
Journal:  Biochim Biophys Acta       Date:  1966-02-01

7.  Metabolism of beta-sitosterol in man.

Authors:  G Salen; E H Ahrens; S M Grundy
Journal:  J Clin Invest       Date:  1970-05       Impact factor: 14.808

8.  Steroid conjugates in plasma. XXIV. Formation of lipophil steroid sulfoconjugates from 7 alpha-3H-DHEA sulfate and carboxyl-14C diglyceride.

Authors:  P Benes; M Schirazi; G W Oertel
Journal:  Steroids Lipids Res       Date:  1973
  8 in total
  3 in total

1.  Metabolism of sitosteryl beta-D-glucoside and its nutritional effects in rats.

Authors:  N Weber
Journal:  Lipids       Date:  1988-01       Impact factor: 1.880

2.  Precursors of the neurosteroids.

Authors:  V V Prasad; S R Vegesna; M Welch; S Lieberman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

3.  Steroids and their conjugates in the mammalian brain.

Authors:  C Mathur; V V Prasad; V S Raju; M Welch; S Lieberman
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205
  3 in total

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