Literature DB >> 3857186

Tricyclic antidepressants antagonize prostaglandin (PG) E2-induced contractions of the guinea pig ileum and hypomotility in the mouse.

F M Tayo.   

Abstract

The interactions of PGE2 and 2 tricyclic antidepressants were tested both on the guinea pig ileum and motility in the mouse. PGE2-induced contractions of the guinea pig ileum were irreversibly blocked by amitriptyline and desipramine. Chronic administration of amitriptyline and desipramine blocked PGE2-induced hypomotility in the mouse.

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Year:  1985        PMID： 3857186     DOI： 10.1007/bf01966154

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  DIFFERENCES IN THE EFFECTS OF PROSTAGLANDIN F2-ALPHA, A CONSTITUENT OF CEREBRAL TISSUE, AND PROSTAGLANDIN E1 ON CONSCIOUS CATS AND CHICKS.

Authors:  E W HORTON; I H MAIN
Journal:  Int J Neuropharmacol       Date:  1965-04

Review 2.  Review of the pharmacology of existing antidepressants.

Authors:  P S Spencer
Journal:  Br J Clin Pharmacol       Date:  1977       Impact factor: 4.335

Review 3.  The catecholamine hypothesis of affective disorders: a review of supporting evidence.

Authors:  J J Schildkraut
Journal:  Am J Psychiatry       Date:  1965-11       Impact factor: 18.112

4.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03
  4 in total

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