Literature DB >> 3855968

Acute changes in blood-CSF barrier permselectivity to serum proteins after intrathecal methotrexate and CNS irradiation.

P Livrea, M Trojano, I L Simone, G B Zimatore, G C Logroscino, L Pisicchio, G Lojacono, R Colella, A Ceci.   

Abstract

Ten children affected by acute lymphoblastic leukaemia without CNS involvement were treated with a CNS prophylaxis protocol. Intrathecal methotrexate and CNS irradiation (60Co) administered at different times both induced an increase in blood-CSF barrier permeability to serum proteins (albumin, IgG, alpha 2 macroglobulin). The relationship between permeability coefficients of proteins was analysed by theoretical porous or vesicular blood-CSF barrier models. The analysis indicated that both therapeutic procedures affect endothelial pinocytosis. An increase in radius of pinocytotic vesicles from 400 to 1500 A seemed the most relevant change. The damage of endothelial barrier permselectivity could be involved in acute and late delayed toxic effects of intrathecal methotrexate and of CNS irradiation.

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Year:  1985        PMID： 3855968     DOI： 10.1007/bf00313712

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  16 in total

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Authors:  B van Deurs
Journal:  Int Rev Cytol       Date:  1980

2.  Prophylactic CNS therapy in childhood acute leukemia: review of methods used.

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Journal:  Am J Pediatr Hematol Oncol       Date:  1979

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Authors:  T Schettler; C N Shealy
Journal:  J Neurosurg       Date:  1970-01       Impact factor: 5.115

4.  Intrathecal IgG synthesis in multiple sclerosis: comparison between isoelectric focusing and quantitative estimation of cerebrospinal fluid IgG.

Authors:  P Livrea; M Trojano; I L Simone; G B Zimatore; G Lamontanara; R Leante
Journal:  J Neurol       Date:  1981       Impact factor: 4.849

5.  Heterogeneous models for blood-cerebrospinal fluid barrier permeability to serum proteins in normal and abnormal cerebrospinal fluid/serum protein concentration gradients.

Authors:  P Livrea; M Trojano; I L Simone; G B Zimatore; L Pisicchio; G Logroscino; G Cibelli
Journal:  J Neurol Sci       Date:  1984-06       Impact factor: 3.181

6.  Evaluation of the blood-CSF barrier by protein gradients and the humoral immune response within the central nervous system.

Authors:  K Felgenhauer; G Schliep; N Rapic
Journal:  J Neurol Sci       Date:  1976-11       Impact factor: 3.181

7.  Brain damage in relation to irradiation and chemotherapy of central nervous system.

Authors:  S Similä; E Heikkinen; G Blanco; P J Taskinen; K Kouvalainen; M Lanning; A L Saukkonen
Journal:  Lancet       Date:  1977-05-07       Impact factor: 79.321

8.  Expanding the definition of the blood-brain barrier to protein.

Authors:  R D Broadwell; M Salcman
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

9.  Changes of CSF-protein pattern in children with acute lymphoblastic leukemia during prophylactic CNS therapy (Berlin protocol).

Authors:  H Siemes; D Rating; M Siegert; F Hanefeld; S Müller; H Gadner; H Riehm
Journal:  Med Pediatr Oncol       Date:  1980

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Authors:  B van Deurs; J K Koehler
Journal:  J Cell Biol       Date:  1979-03       Impact factor: 10.539
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  12 in total

1.  Correlation between protein data in normal lumbar CSF and morphological findings of choroid plexus epithelium: a biochemical corroboration of barrier transport via tight junction pores.

Authors:  H Kluge; W Hartmann; B Mertins; V Wieczorek
Journal:  J Neurol       Date:  1986-08       Impact factor: 4.849

2.  Effect of dexamethasone on postoperative symptoms in patients undergoing elective laparoscopic cholecystectomy: randomized clinical trial.

Authors:  Petra-Evelyn Sánchez-Rodríguez; Clotilde Fuentes-Orozco; Alejandro González-Ojeda
Journal:  World J Surg       Date:  2010-05       Impact factor: 3.352

3.  Effect of a preoperative single-dose steroid on pulmonary function and postoperative symptoms after modified radical mastectomy: results of a randomized clinical trial.

Authors:  Jorge Jiménez-Tornero; Ana Olivia Cortés-Flores; Mariana Chávez-Tostado; Gilberto Morgan-Villela; Carlos Zuloaga-Fernández Del Valle; Raymundo Zuloaga-Fernández Del Valle; Luis Alberto García-González; Vanesa Sarahí Fernández-Avalos; Roberto Carlos Miranda-Ackerman; Andrea Socorro Alvarez-Villaseñor; Gabriela Ambriz-González; Francisco José Barbosa-Camacho; Clotilde Fuentes-Orozco; Vianca Seleste Contreras-Cordero; Alejandro González-Ojeda
Journal:  Gland Surg       Date:  2020-10

4.  Reduction of postoperative nausea, vomiting, and analgesic requirement with dexamethasone for patients undergoing laparoscopic cholecystectomy.

Authors:  Y Fujii; M Itakura
Journal:  Surg Endosc       Date:  2009-08-19       Impact factor: 4.584

5.  Effects of ramosetron and dexamethasone on postoperative nausea, vomiting, pain, and shivering in female patients undergoing thyroid surgery.

Authors:  Yoon-Kang Song; Cheol Lee
Journal:  J Anesth       Date:  2012-09-11       Impact factor: 2.078

6.  Brain lesions following combined treatment with methotrexate and craniospinal irradiation.

Authors:  F F Cruz-Sanchez; J Artigas; J Cervos-Navarro; M L Rossi; R Ferszt
Journal:  J Neurooncol       Date:  1991-04       Impact factor: 4.130

7.  Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer.

Authors:  Jorge Gómez-Hernández; Alba Lorena Orozco-Alatorre; Marisela Domínguez-Contreras; Antonio Oceguera-Villanueva; Salvador Gómez-Romo; Andrea Socorro Alvarez Villaseñor; Clotilde Fuentes-Orozco; Alejandro González-Ojeda
Journal:  BMC Cancer       Date:  2010-12-23       Impact factor: 4.430

8.  Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids.

Authors:  T J Hursti; M Fredrikson; G Steineck; S Börjeson; C J Fürst; C Peterson
Journal:  Br J Cancer       Date:  1993-07       Impact factor: 7.640

9.  Dexamethasone can potentiate the anti-emetic action of a 5HT3 receptor antagonist on cyclophosphamide induced vomiting in the ferret.

Authors:  J Hawthorn; D Cunningham
Journal:  Br J Cancer       Date:  1990-01       Impact factor: 7.640

10.  5-Hydroxyindoleacetic acid (5-HIAA) and cortisol excretion as predictors of chemotherapy-induced emesis.

Authors:  A du Bois; W Vach; U Wechsel; R Holy; W Schaefer
Journal:  Br J Cancer       Date:  1996-10       Impact factor: 7.640
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