Literature DB >> 3853964

Comparative in vitro activity of coumermycin against methicillin-resistant Staphylococcus aureus.

B R Meyers, E S Srulevitch, S Z Hirschman.   

Abstract

Coumermycin was the most active agent in vitro against methicillin-resistant Staphylococcus aureus when compared with fusidic acid, imipenem, rifampin, trimethoprim-sulfamethoxazole, and vancomycin. The MICs of coumermycin ranged from 0.002 to greater than 4 micrograms/ml and from 0.5 to greater than 4 micrograms/ml for inocula of 10(4) and 10(6) CFU/ml, respectively. The combination of coumermycin with either cephalothin or ciprofloxacin showed some synergy; antagonism was found with gentamicin.

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Year:  1985        PMID： 3853964      PMCID： PMC176365          DOI： 10.1128/AAC.28.5.706

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.

Authors:  G B ELION; S SINGER; G H HITCHINGS
Journal:  J Biol Chem       Date:  1954-06       Impact factor: 5.157

2.  In vitro studies of the activity of coumermycin-A1 against staphylococci resistant to methicillin and cephalothin.

Authors:  D Michaeli; B Meyers; L Weinstein
Journal:  J Infect Dis       Date:  1969-10       Impact factor: 5.226

3.  Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

Authors:  M Gellert; M H O'Dea; T Itoh; J Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

4.  Rifampin: mechanisms of action and resistance.

Authors:  W Wehrli
Journal:  Rev Infect Dis       Date:  1983 Jul-Aug

5.  Failure to prevent emergence of bacterial resistance by combination of two antibiotics: fusidic acid and rifampicin.

Authors:  R N Grüneberg; A M Emmerson
Journal:  J Antimicrob Chemother       Date:  1980-07       Impact factor: 5.790

6.  The emergence of methicillin-resistant Staphylococcus aureus.

Authors:  R P Wenzel
Journal:  Ann Intern Med       Date:  1982-09       Impact factor: 25.391

7.  Microbiological and pharmacological study of a new antibiotics, coumermycin A1.

Authors:  D Michaeli; B R Meyers; L Weinstein
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1969

8.  Emergence of gentamicin- and methicillin-resistant Staphylococcus aureus strains in New York City hospitals.

Authors:  S Schaefler; D Jones; W Perry; L Ruvinskaya; T Baradet; E Mayr; M E Wilson
Journal:  J Clin Microbiol       Date:  1981-04       Impact factor: 5.948

9.  In vitro activities of teichomycin, fusidic acid, flucloxacillin, fosfomycin, and vancomycin against methicillin-resistant Staphylococcus aureus.

Authors:  S H Guenthner; R P Wenzel
Journal:  Antimicrob Agents Chemother       Date:  1984-08       Impact factor: 5.191

10.  Antibacterial activity of coumermycin alone and in combination with other antibiotics.

Authors:  H C Neu; N X Chin; P Labthavikul
Journal:  Antimicrob Agents Chemother       Date:  1984-06       Impact factor: 5.191
  10 in total
  1 in total

1.  Treatment of Staphylococcus aureus endocarditis in rats with coumermycin A1 and ciprofloxacin, alone or in combination.

Authors:  C M Perronne; R Malinverni; M P Glauser
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191
  1 in total

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