Literature DB >> 38504

Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment.

N C Bacopoulos, E G Spokes, E D Bird, R H Roth.   

Abstract

In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with drugs.

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Year:  1979        PMID： 38504     DOI： 10.1126/science.38504

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

Review 1.  Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system.

Authors:  G B Baker; A J Greenshaw
Journal:  Cell Mol Neurobiol       Date:  1989-03       Impact factor: 5.046

2.  Time-response curves of homovanillic acid in caudate and pre-frontal cortex following acute neuroleptic administration.

Authors:  W H Chang; T Y Chen; E K Yeh
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

3.  A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex.

Authors:  M S Lidow; P S Goldman-Rakic
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

4.  Presynaptic dopamine receptors: insensitivity to kainic acid and the development of supersensitivity following chronic haloperidol.

Authors:  M J Bannon; E B Bunney; J R Zigun; L R Skirboll; R H Roth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-06       Impact factor: 3.000

5.  Effects of ceruletide on the dopamine receptor-adenylate cyclase system in striatum and frontal cortex of rats chronically treated with haloperidol.

Authors:  Y Hatta; S Hatta; T Saito
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

6.  Lithium does not interact with haloperidol in the dopaminergic pathways of the rat brain.

Authors:  A Reches; V Jackson-Lewis; S Fahn
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

7.  Homovanillic acid in caudate and pre-frontal cortex following acute and chronic neuroleptic administration.

Authors:  M B Bowers; F J Hoffman
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

8.  Dopamine metabolism increases in post-mortem schizophrenic basal ganglia.

Authors:  M Toru; T Nishikawa; N Mataga; M Takashima
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

9.  Chronic haloperidol administration increases the density of D2 dopamine receptors in the medial prefrontal cortex of the rat.

Authors:  A J MacLennan; S Atmadja; N Lee; H C Fibiger
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

Review 10.  The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrine.

Authors:  J N Joyce
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530
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