| Literature DB >> 3850020 |
Abstract
A new iterative polyexponential curve stripping technique for the provision of initial pharmacokinetic parameter estimates has been developed. Such estimates are required for nonlinear least-squares curve fitting. In contrast to conventional curve stripping, this new technique does not make any assumption about the relative magnitudes of the exponential rate constants. Hence, the parameter estimates which it provides are free of the bias which may arise in conventional curve stripping. A BASIC program called JANA has been developed to implement the new curve stripping procedure.Mesh:
Year: 1985 PMID: 3850020 DOI: 10.1016/0169-2607(85)90085-9
Source DB: PubMed Journal: Comput Methods Programs Biomed ISSN: 0169-2607 Impact factor: 5.428